抵抗素研究进展及其在肿瘤核医学中的应用  

Progress of study on resistin and its application in tumor nuclear medicine

作　　者：陈仲[1] 韩佩珍[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所天津市分子核医学重点实验室,天津300192

出　　处：《国际放射医学核医学杂志》2007年第3期138-140,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：抵抗素是脂肪细胞分泌的一种多肽类细胞因子，是肥胖与胰岛素抵抗和糖尿病联系的纽带，其在体内分布广泛，但现阶段研究还存在很大的争议。目前，抵抗素的检测方法主要是酶联免疫吸附分析、相对定量实时聚合酶链反应技术、放射免疫分析和蛋白质印迹法。乳腺癌患者血清抵抗素水平为（5．23±6．90）mg／L，明显高于对照组的（1．46±2．00）mg／L。通过对抵抗素在肿瘤核医学中的应用研究，可进一步研究其与乳腺癌在分子水平上的关系。Resistin, a peptide cell factor secreted by fat cells, has wide distributiion in human body and multiple functions. Although resistin probably is a bridge connecting obesity to insulin resistance and diabetes, there are lots of controversies and diseonformations among recent studies. So far, the detection method of resistin is enzyme linked immunosorbent assay, relative quantitative real-time PCR, radioimmunoassay and Western blotting. There was a statistically significant difference in serum resistin levels between the groups （breast cancer group 5.23±6.90 mg/L vs. control 1.46±2.00 mg/L）. The studies of resistin in application in tumor nuclear medicine will investigate the relationgship of resistin and breast cancer further in the molecular level.

关 键 词：酶联免疫吸附测定 聚合酶链反应 放射免疫测定 印迹法 蛋白质 抵抗素 

分 类 号：R730[医药卫生—肿瘤]