The synthesis and activity in vitro of a series of 8-difluoromethoxy quinolones: Analogues of gemifloxacin  

作　　者：Jin Jiang Jiu Yu Liu Hui Yuan Guo 

机构地区：[1]Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100050, China

出　　处：《Chinese Chemical Letters》2007年第10期1169-1172,共4页中国化学快报（英文版）

摘　　要：7-[4-（Aminomethyl）-3-（methoxyimino）pyrrolidin- 1-yl]- 1-cyclopropyl-6-fluoro-8-difluoromethoxy- 1,4-dihydro-4-oxoquino- line-3-carboxylic acid and its analogues have been prepared and evaluated for antibacterial activity in vitro.7-[4-（Aminomethyl）-3-（methoxyimino）pyrrolidin- 1-yl]- 1-cyclopropyl-6-fluoro-8-difluoromethoxy- 1,4-dihydro-4-oxoquino- line-3-carboxylic acid and its analogues have been prepared and evaluated for antibacterial activity in vitro.

关 键 词：QUINOLONE SYNTHESIS Antibacterial activity 

分 类 号：TQ465[化学工程—制药化工]