COX-2、VEGF、Ki67在子宫内膜癌中的表达及意义  

Expression of COX-2,VEGF and Ki67 in endometrial carcinoma

作　　者：胡向荣[1] 刁路明[2] 赵碧芬[1] 王伟新[1] 

机构地区：[1]浙江省丽水市人民医院病理科,丽水323000 [2]武汉大学医学院病理教研室

出　　处：《实用肿瘤学杂志》2007年第5期430-431,434,共3页Practical Oncology Journal

摘　　要：目的探讨环氧合酶-2(COX-2)、血管内皮生长因子(VEGF)和增殖细胞核相关抗原(Ki67)在子宫内膜癌发生、发展中的作用。方法采用免疫组织化学Envision法检测50例子宫内膜癌和15例正常子宫内膜组织中COX-2、VEGF、Ki67的表达。结果子宫内膜癌组织中COX-2、VEGF、Ki67的表达明显高于正常子宫内膜组织(P<0.01);COX-2的高表达与临床分期无关(P>0.05),与分化程度和浸润深度有关(P<0.01);VEGF的高表达与临床分期、浸润深度无关(P>0.05),分化程度有关(P<0.05);Ki67的高表达与临床分期(P<0.05)、分化程度、浸润深度有关(P<0.01)。COX-2与VEGF和Ki67的表达间存在正相关(r=0.39,P<0.01;r=0.32,P<0.05)。结论COX-2、VEGF、Ki67与子宫内膜癌的发生和发展相关,COX-2可通过使VEGF高表达,增加细胞增殖活性促进子宫内膜癌的发生、发展。Objective To explore the significance of COX-2, VEGF and Ki-67 in the pathogenesis and development of endometrial carcinoma. Methods Expression of COX-2, VEGF and Ki67 was examined in 50 cases of endometrial carcinoma and 15 cases of normal endometrial tissues by immunohistochemical method Envision. Results Expression of COX-2, VEGF and Ki67 in endometrial carcinoma was strikingly trigber than that in the normal counterpart （ P 〈 0.01 ）. High expression of COX-2 was associated with tumor differentiation and depth of invasion （ P 〈 0.01 ） but was not related to clinical stage （ P 〉 0.05 ）. High expression of VEGF was associated with tumor differentiation （ P 〈 0.05 ） but was not related to clinical stage and depth of invasion （ P 〉 0.05）. High expression of Ki67 was associated with clinical stage（ P 〈 0.05）, tumor differentiation and depth of invasion （ P 〈 0.01 ）. Expression of COX-2 was positively correlated with the expression of VEGF and Ki67（ r = 0.39, P 〈 0.01 ; r = 0.32, P 〈 0.05 ）. Conclusion COX-2, VEGF and Ki67 were involved in the pathogenesis and development of endometrial carcinoma. COX-2 ,nay function by increasing the expression of VEGF to promote the proliferation of cells.

关 键 词：子宫内膜癌 COX-2 VEGF KI67 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]