病理状态HERG/I_(Kr)通道角色及中药干预的研究  

Modulation of HERG/I_(Kr) in pathological condition and effect of traditional chinese medicine on HERG/I_(Kr)

作　　者：周宇宏[1] 杨宝峰[1] 李宝馨[1] 

机构地区：[1]哈尔滨医科大学药理学教研室,黑龙江哈尔滨150086

出　　处：《中国药理学通报》2007年第10期1264-1267,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目资助课题(No30430780);国家自然科学基金资助课题(No30572181)

摘　　要：HERG/IKr通道在心脏动作电位复极化过程中发挥重要作用。在许多病理条件下例如心肌肥厚、心肌梗死和充血性心力衰竭HERG/IKr电流大小和通道动力学特性常发生改变。该文就疾病状态下HERG/IKr通道的改变及中药干预作用作一综述。HERG/IKr plays an important role in repolarization of cardiac action potential. In pathological condition such as cardiac ischemia, congestive heart failure and myocardial hypertrophy, the density and kinetic properties of HERG/IKr will change. This review is about modulation of HERG/Ikr in pathological condition and effect of traditional chinese medicine on HERG/IKr.

关 键 词：HERG/Ikr 通道 疾病 中药 

分 类 号：R-05[医药卫生] R282.710.5