不同分割照射同时化疗对人肺腺癌的杀伤作用  

The Influence of Different Fractionated Irradiation Concomitant with Chemotherapy on Human lung Adenocarcinoma

作　　者：张大昕[1] 高永君[1] 吴敏[1] 陈林[1] 田长富 王波 胡晓敏 

机构地区：[1]哈尔滨医科大学附属第三医院,150040 [2]黑龙江省肿瘤研究所

出　　处：《肿瘤防治研究》1997年第3期160-162,共3页Cancer Research on Prevention and Treatment

基　　金：黑龙江省卫生厅资助

摘　　要：本实验用体外细胞克隆培养和体内实验处理离体细胞克隆培养这两种技术，观察了5-FuDDP联合辐射对人肺腺癌Anip－973细胞及实体瘤的杀伤作用。结果，联合给药+常规分割照射的细胞存活率为9．6％；细胞实验的剂量修饰因子（DMF）值为2．2，动物实体瘤DMF为2．0；联合给药+超分割照射的细胞存活率为17．3％，细胞实验DMF值为1．9，动物实体瘤为1．5；单纯给药组的细胞存活率为75％；2GY照射的细胞存活率为76．7％。结论：5-Fu＋DDP联合照射有明显的协同作用；放-化同时使用时，常规分割照射对肿瘤的杀伤大于超分割照射。The effect of different fractionated irradiation concomitant with 5-Fu DDP was investigated by colony assay in vitro directely and after in vivo chemo-irradiation of tumor-bearing nude mice. The result showed that cell survival rate and Dose Modi fier Factor(DMF) of the drugs combined with 2GY single dose and 1GY ×2 one day irradiation were 9.6%, 17.3% and 2.2, 1.9 respectively in cellular experiment;DMF of the drugs concomitant with conventional and hyperfractioned irradiation were 2. 0 and 1. 5 in tumor experiment. The conclusion were than combinationof two drugs with radiation significantly enhanced cytocidal effect; conventional radiation combined with drugs has greater cytoctony than hyperfractionated irradiation with the drugs.

关 键 词：5-氟尿嘧啶 顺铂 肺肿瘤 腺癌 放射疗法 

分 类 号：R734.205[医药卫生—肿瘤] R730.58[医药卫生—临床医学]