2,3,6-三甲基-7-氨基吡唑并[1,5-a]嘧啶的合成  

Synthesis of 2,3,6-trimethyl-7-amino-pyrazolo-[1,5-a]pyrimidine

作　　者：万成斌[1] 李扬扬[2] 刘超[1] 朱宏吉[1] 

机构地区：[1]天津大学化工学院,天津300072 [2]西安市公安局刑事侦察局技术处,陕西西安710016

出　　处：《中国医药导报》2007年第11Z期85-86,共2页China Medical Herald

摘　　要：目的:研究2,3,6-三甲基-7-氨基吡唑并[1,5-a]嘧啶的合成方法。方法:α-甲基乙酰乙腈在乙醇和乙酸存在的条件下与水合肼反应约60min,经减压蒸馏后,所得产物再与2-甲基-3,3-二甲氧基丙腈反应8h,经20%的NaOH溶液、乙醇处理后,得目标产物。结果:两步反应总产率为42.2%,并对目标物质进行了分析鉴定和结构表征。结论:该合成路线简便,反应条件温和,产率适中,具有较好的应用前景。Objective：To prepare 2,3,6-trimethyl-7-amino-pyrazolo-[1,5-a]pyrimidine by the reaction of 3-amino-4,5- dimethyl-pyrazole with 3,3-dimethoxy-2-methyl-propanenitrile. Methods：At 75℃ for 8 hours in the presence of ethanol and acetic acid, cyclization reaction was carried out smoothly. Results：Total yield of 42.2% was obtained. The title compound was haracterized by 1H-NMR, IR, GC-MS and elementary analysis. Conclusion：The preparation method of 2,3,6- trimethyl-7-amino-pyrazolo-[1,5-a]pyrimidine is more available with a mild reaction condition and a good yield.

关 键 词：3-氨基-4 5-二甲基吡唑 2 3 6-三甲基-7-氨基吡唑并[1 5-a]嘧啶 合成 

分 类 号：R914.5[医药卫生—药物化学]