胃肠道恶性肿瘤患者生命质量影响因素的FLIC问卷评估  

Factors affecting the quality of life in gastrointestinal cancer patients measured by FLIC questionnaire

作　　者：陈鹏[1] 王海江[1] 朱琳[2] 凤小花[1] 贾蕊[1] 

机构地区：[1]新疆医科大学附属肿瘤医院腹部外科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院科研科,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2007年第8期840-842,845,共4页Journal of Xinjiang Medical University

摘　　要：目的：评估胃癌、大肠癌患者的生命质量,探讨与之相关的影响因素。方法：自2005年2月至2006年8月,采用癌症病人生活功能指数（FLIC）问卷调查了52例胃癌患者和50例大肠癌患者,分析患者的年龄、性别、文化程度、病种、TNM分期及治疗情况与患者FLIC得分的关系,并应用最优尺度回归分析、多重线性回归分析和判别方程了解生命质量各功能指标与病期的关系。结果：不同年龄、不同性别、不同文化程度患者间FLIC各功能指标的评分差异均无统计学意义（P〉0.05）;胃癌患者躯体良好及能力评分低于大肠癌,而恶心评分高于大肠癌（P〈0.05）;Ⅰ-Ⅱ期患者躯体良好及能力评分明显低于Ⅲ-Ⅳ期患者,心理良好、因癌困难、社会良好评分均高于Ⅲ-Ⅳ期患者（P〈0.05）;尚未治疗的患者心理良好、因癌困难、社会良好评分均低于经过综合治疗的患者（P〈0.05）;最优尺度回归、判别分析、多重线性回归分析均有因癌困难此项因素进入方程。结论：早期患者、经过综合治疗后的患者的生命质量较好;年龄、性别对生命质量的影响不大;以手术为主的综合治疗措施可以在一定程度上提高患者的生命质量。生命质量应成为评价恶性肿瘤治疗疗效的指标之一。Objective： To evaluate the QoL of patients with gastric cancer and colorectal cancer and to investigate the differences in QoL with respect to social and medical characteristics. Methods： Structured questionnaires Functional Living Index Cancer （FLIC） was used in 52 cases with gastric cancer and 50 cases with colorectal cancer for data collection since February 1, 2005 to August 31, 2006. The T-test and oneway analysis of variance （ANOVA） were used to compare the differences in QoL at a 5% level of significance for the patients in differences of years of age, gender, education, disease, TNM stages, and treatment. Optimal scaling regression, multiple linear regression and discriminant analysis were used to find the relationship of the stages among the domains of FLIC. Results： No significance （P 〉0.05）among the domains of FLIC and the patients in differences years of age, gender and education. Gastric cancer patients had lower ＂Physical well-being and ability＂ score and higher ＂nausea＂ score than colorectal cancer patients （P 〈0.05）. The stages Ⅰ-Ⅱ patients had higher ＂Physical well-being and ability＂, ＂psychological wellbeing＂, patients before treatment and ＂social well-being＂ score than stages Ⅲ-Ⅳ patients （P 〈0.05）.The patients before treatment had lower ＂Psychological well-being＂, ＂Hardship due to cancer＂ and ＂Social well-being＂ score than patients after treatment （P 〈0.05）. ＂Hardship due to cancer＂ could come into all of the equations, such as optimal scaling regression, multiple linear regression and discriminant analysis. Conclusion：The patients in early stages, or having experienced the combined therapy, had better QoL. Years of age and gender had no influence in QoL. The combined therapy that included operation as a primary treatment can elevate the QoL of patients on certain extent. The QoL should be used as an indicatrix for curative effect evaluation of cancer treatment.

关 键 词：生命质量 胃肿瘤 大肠肿瘤 癌症病人生活功能指数 

分 类 号：R735.2[医药卫生—肿瘤] R735.34[医药卫生—临床医学]