肿瘤相关纤维母细胞的研究进展  

Advances in the study of carcinoma-associated fibroblasts

作　　者：居旻杰[1] 邱双健[1] 汤钊猷[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所

出　　处：《中国癌症杂志》2007年第10期819-823,共5页China Oncology

基　　金：教育部科学技术研究重点项目(项目编号:107039)

摘　　要：肿瘤的生物学特性不仅是由癌基因和抑癌基因来调控的,还依赖于由其间质等构成的微环境。基膜、免疫细胞、毛细血管、纤维母细胞和细胞外基质(extracellular matrix,ECM)共同构成肿瘤间质,与创伤愈合过程中的间质相似,肿瘤间质亦为活化的间质(reactive stroma)。而纤维母细胞是活化间质中的主要功能细胞,其与肿瘤的发生发展的关系日益成为研究的热点。本文旨在探讨肿瘤相关纤维母细胞(carcinoma-associated fibroblasts,CAF)的生物学特点及研究进展及方向。The biological characteristic of carcinomas is determined both by the stromal microenvironment and the oncogene or anti-oncogene. The tumor stroma is also known as the reactive stroma which is composed of base member, immunocell, capillary, fibroblasts and ECM. Fibroblasts are the majority of tumor stromal cells. The relationship between fibroblasts and the initiation, progression of carcinoma has being in the spot light. In this review, we summarized the advance in the study of carcinoma-associated fibroblasts.

关 键 词：肿瘤 间质 肿瘤相关纤维母细胞 

分 类 号：R730[医药卫生—肿瘤]