非甾体类抗炎药物与消化性溃疡出血  

Correlation between Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Bleeding

作　　者：曾美仪[1] 伍俊妍[1] 陈楚雄[1] 张世能[2] 黄开红[2] 陈为宪[2] 王连源[2] 

机构地区：[1]中山大学附属第二医院药学部,510120 [2]中山大学附属第二医院消化内科,510120

出　　处：《岭南急诊医学杂志》2007年第5期342-344,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨非甾体类抗炎药物(NSAIDs)诱发消化性溃疡(peptic ulcer,PU)出血的临床流行病学特点。方法:调查我院1996年1月～2006年1月间因PU并出血收住院治疗患者的临床资料,根据入院前1周内有无服用NSAIDs史将患者分为2组,对2组病人的临床资料进行分析比较。结果:本研究共纳入1012例患者,其中服药组386例,未服药组626例。2组病人在性别、出血方式、既往PU史、胃及十二指肠溃疡的具体部位、糜烂,以及是否需要内镜治疗等方面的差异无显著性。但是服药组患者的年龄较未服药组更高;胃溃疡和复合溃疡、多发溃疡在服药组更多见(P<0.05)。结论:应加强对NSAIDs相关性PU并出血临床特点的认识,尽量减少NSAIDs的不良反应。Objective: To investigate the clinical epidemiological features of peptic ulcer(PU)bleeding induced by nonsteriodalanti-inflammatory drugs (NSAIDs). Methods: Patients who were hospitalized in our ward because of gastroduodenal bleeding from Jan, 1996 to Jan, 2006 were divided into two groups according to consumption of NSAIDs or not in the week previous to the onset of bleeding. Results: 1012 patients were investigated with 386 in NSAIDs group and 626 in non-NSAIDs group. There was no significant difference in sex, way of bleeding, history of peptic ulcer, bleeding site in stomach or duodenum, presence of erosion and the need of endoscopic injection therapy or not between the two groups. However, the patients in NSAIDs group were older than those in non-NSAIDs group. There was more gastric ulcer and complex ulcer in the NSAIDs group than in non-NSAIDs group (P < 0.05). NSAIDs users had more ulcers (P < 0.05). Conclusions: The clinical characteristics of NSAIDs associated gastroduodenal bleeding should be better understood so as to decrease the occurrence of NSAIDs ulcer and its complication.

关 键 词：消化性溃疡 非甾体类抗炎药 流行病学 

分 类 号：R573.2[医药卫生—消化系统]