^(18)F-FDG PET显像在肺癌预后评价中的应用  

The prognostic value of ^(18)F-FDG PET/CT in lung cancer

作　　者：陈香[1] 赵军[1] 管一晖[1] 陆舜[2] 左传涛[1] 华逢春[1] 

机构地区：[1]复旦大学附属华山医院 PET 中心,上海200235 [2]上海市胸科医院

出　　处：《中华核医学杂志》2007年第5期269-272,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨 ^(18)F-FDG PET 显像评价新诊断肺癌患者的预后价值。方法回顾性分析201例新诊断肺癌患者资料,以肺部原发病灶的 SUV 为显像的预后评价指标,采用 SPSS 11.5软件行单因素和多因素生存分析。结果单因素分析显示:TNM 分期、原发病灶大小及 SUV 均为影响预后的重要因素(P<0.05),而性别、年龄与预后无明显相关性(P>0.05)。SUV 对不同分期患者的预后价值不同,对Ⅲ期患者预后评价的价值最大。Cox 比例风险模型分析显示:TNM 分期及原发病灶的SUV 是影响预后的最重要的因素(P<0.05)。SUV>8患者的死亡风险是 SUV≤8患者的2.19倍。SUV 每升高"1",患者死亡风险升高7%。结论肺癌原发病灶的 SUV 是独立于 TNM 分期外的另一个重要的预后因子。分期相同的肺癌患者根据 SUV 的不同可以划分为不同危险组,制定个性化的治疗方案。Objective The retrospective study was focused on the prognostic value of ^18F-FDG PET in lung cancer. Methods A total of 201 patients with newly diagnosed lung cancer undergoing PET imaging were retrospectively reviewed in light of their clinical follow-up data. The univariate and multivariate analysis were carried out on the factors concerning survival differences. Results Univariate analysis identified three prognostic factors： TNM stage, lesion size and SUV. SUV was the prognostic indicator for different stages and of the best value for stage Ⅲ disease. Multivariate analysis revealed that TNM stage and SUV were the most important prognostic factors. Patients with SUV 〉 8 had a 2.19 times higher mortality than those with SUV ≤8. A one-unit increase of SUV corresponded with a 7% increase of risk of death. Conclusions The maximum SUV of primary lung lesion is an independent predictor of prognosis in addition to the TNM stage. It may contribute to subdividing patients with the same TNM stage for individually adapted treatment strategies and improving the outcome accordingly.

关 键 词：肺肿瘤 预后 体层摄影术 发射型计算机 脱氧葡萄糖 

分 类 号：R734.2[医药卫生—肿瘤]