黏着斑激酶与肿瘤  

Focal adhesion kinase and cancer

作　　者：胡章颜[1] 刘文庆[1] 刘康达[2] 

机构地区：[1]绍兴文理学院医学院基础医学部,浙江绍兴312000 [2]复旦大学中山医院实验研究中心,上海200032

出　　处：《基础医学与临床》2007年第10期1177-1180,共4页Basic and Clinical Medicine

摘　　要：黏着斑激酶是一种非受体酪氨酸激酶,通过多种信号途径在细胞周期调控、生长调节、黏附、细胞骨架组装、运动、生存等方面发挥重要作用。研究发现,黏着斑激酶在多种肿瘤中高表达,参与肿瘤的发生、发展、侵袭、转移等。黏着斑激酶已成为当前肿瘤研究热点,有可能成为肿瘤治疗的新靶点。Focal adhesion kinase （FAK）, the non-receptor tyrosine kinase, has been implicated in regulating a number of fundamental biological signal transudation pathways that control cell proliferation, survival, adhesion, motility. Many researches have reported that FAK highly expressed in many cancers and involved in the process of cancer development, such as initial, progress, metastasis, multi-drug resistance of cancer. FAK has been the hot-pot in cancer research, and it will be a new target in cancer therapy.

关 键 词：黏着斑激酶 信号传导 肿瘤 治疗 

分 类 号：R730.2[医药卫生—肿瘤]