LASEK术中应用丝裂霉素C预防Haze的临床观察  

The clinical observation of applying mitomycin C in LASEKsurgery to prevent the formation of haze

作　　者：周予兰[1] 王保君[1] 彭坤[1] 千素兰[1] 郑朝艳[1] 李庆和[1] 

机构地区：[1]河南新乡医学院第一附属医院眼科,正辉453100

出　　处：《中国实用眼科杂志》2007年第9期980-982,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 观察丝裂霉素C（MMC）对LASEK术后角膜上皮下雾状混浊（haze）的预防作用。方法 将40例（80眼）准备行LASEK手术的患者随机分为两组,研究组20例在激光切削完成后,将浸有0.02%的MMC海绵片覆盖于角膜切削区,覆盖时间同角膜切削时间;对照组20例不使用任何药物。术后定期随访观察两组角膜上皮愈合情况,视力恢复情况及haze形成情况。结果 研究组无1级以上haze发生,而且haze轻于对照组,视力也较对照组高,两组间差异有统计学意义（P〈0.05）。两组眼部刺激症状和角膜上皮愈合时间差异无统计学意义（P〉0.05）。应用MMC未见明显毒副作用。结论 LASEK术中应用MMC能有效减轻haze的形成,提高视力。Objective To observe the using of mitomycin C in LASEK surgery to prevent the formation of haze under corneal epithelium.Methods 40cases（80 eyes） was randomly divided into two groups,0.02% MMC sponge was put on to the corneal ablation area during the operation in 20 patients（40 eyes）of MMC group,the time is the same as the corneal ablation;The control group 20 cases（40 eyes）did not use any medication.Regular follow-up was done to observe the haze for mation corneal epithelium healing time and recovery of visual acuity of the two groups.Results In MMC group,no eye had a haze rate higher than stage 1 and the haze is lighter than that of control group,the postoperative uncorrected visual acuity is higher than that of control group（p〈0. 05）.There is no difference of ocular irritation symptom and corneal epithelium healing time between the 2 groups（p〉0.05）.Conclusions The application of 0.02% MMC duringLASEK operation could reduce the formation of haze.There is no side effect.

关 键 词：丝裂霉素C LASEK HAZE 

分 类 号：R779.63[医药卫生—眼科]