近视眼激光原位角膜磨镶术后眼压变化及真实眼压评估  

Change in intraocnlar pressure in myopic eyes after laser in situ keratomi leusis and assessment of actual intraocular pressure

作　　者：周少博[1] 胡群英[1] 路晓明[1] 洪海峰[1] 麦庆怡[1] 黎健菁[1] 

机构地区：[1]广州医学院第一附属医院,广州510120

出　　处：《中国实用眼科杂志》2007年第9期986-988,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 研究近视眼激光原位角膜磨镶术（LASIK）后的眼压变化并建立一个真实眼压估计的统计模型。方法 分别对47例（93眼）接受LASIK手术近视眼患者在术前和术后至少6月以上用非接触气动眼压计进行眼压测量,同时测量手术前后的中央角膜厚度和中央角膜曲率,比较手术前后的眼压变化,并利用术后眼压以及中央角膜厚度和角膜曲率的变化通过多变量线性回归法建立一个估计真实眼压的模型。结果 术后眼压测量值比术前下降（5.65±1.71）mmHg,差异有显著性,t=8.65,P=0.00。术前眼压（代表真实眼压）与术后眼压、术前后中央角膜厚度下降率和中央角膜曲率差显著相关,P=0.00,R2=0.73。结论 近视眼LASIK术后眼压测量值偏低,尽管可以利用术后眼压和角膜厚度及曲率的变化建立一个估计真实眼压的统计模型,但其它的相关影响因素仍需要进一步了解。Subjective To investigate the changeof intraocular pressure after myopic laser in situ keratomileusis（LASIK）and develop a predictive model for real intraocular pressure.Methods This prospective clinical trial comprised 93 eyes of 47 patients with myopia and myopic astigmatism that underwent LASIK. Preoperatively and at lest 6 months postoperatively intraocular pressure by noncontact air-puff tonometry, central corneal curvature by topography,and central corneal thickness by ultrasound packymetry were evaluated. The preoperative intraocular pressure was compared with the postoperative intraocular pressure. Postoperative intraocular pressure,difference of central corneal curvature between preoperative and postoperative,proportion of reduction of central corneal thickness were applied for predicting real intraocular pressure based on linear regression model.Results Postoperative intraocular pressure lowered for（5.65 ± 1.71）mmHg compared that of preoperative,the differenc was significant using student＇s t test, t=8.65,P=0.00.Preoperative intraocular pressure （represented real intraocular pressure） was signicant correlated with postoperative intraocular pressure,diffence of central corneal curvature,and proportion of reduction of central corneal thickness,P=0.00,R^2=0.73. Conclusions Intraocular pressure assessment is underestimated in patients with myopic LASIK.Although correction formulas can be used toestimate the actual intraocular pressure,other variations independent of corneal thickness and curvature should be investigated.

关 键 词：角膜屈光手术 眼压 近视 

分 类 号：R778.11[医药卫生—眼科]