肿瘤转移研究新动态——干细胞“归巢”?  

New Investigation Developments of Tumor Metastasis——Homing of Stem Cell?

作　　者：柳瑞军[1] 钟竑[1] 

机构地区：[1]上海交通大学医学院附属新华医院胸心外科,上海200092

出　　处：《中国胸心血管外科临床杂志》2007年第5期376-379,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：肿瘤干细胞的转移与归巢和肿瘤转移的步骤基本相似,肿瘤的转移可以形象地称为肿瘤干细胞的"归巢"。肿瘤干细胞脱离原发病灶,外渗到细胞外基质,促进血管的生成或细胞内渗,从而进入循环系统,逃避宿主的防御机制,通过趋化作用迁移到特定的血管位点,黏附,然后再外渗出血管而归巢到特定的微环境,形成转移灶。现就肿瘤干细胞的归巢和转移步骤进行综述。The metastasis and homing of tumor/cancer stem cell is closely similar to the metastatic step of tumor/cancer. Tumor/cancer metastasis can vividly termed the tumor/cancer stem cell ＂homing＂. Tumor/cancer stem cells must first detach from the primary tumor, extravasate to extracellular matrix, stimulate angiogenesis or intravasate and migrate through the systemic circulation, evade host defense mechanisms, migrate to specific blood vessel sites through chemotaxis and attach to blood vessel wall, then extravasate through blood vessel and home to specific microenvironment and to form metastases. The homing and metastatic steps of tumor/cancer stem cell will be discussed in this article.

关 键 词：肿瘤 肿瘤干细胞 干细胞 转移 归巢 

分 类 号：R73-3[医药卫生—肿瘤]