肺癌组织中突变型p53与Cox-2蛋白的相关性  

Correlation of mutated p53 with Cox-2 protein in lung cancer

作　　者：孙丽梅[1] 赵月[1] 王鲁建[2] 宋敏[1] 宋继谒[1] 

机构地区：[1]中国医科大学基础医学院病理学教研室,沈阳110001 [2]中国医科大学基础医学院人体解剖学教研室,沈阳110001

出　　处：《临床与实验病理学杂志》2007年第5期593-596,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨突变型p53和Cox-2蛋白在肺癌组织中表达的相关性及其对预后的影响。方法应用免疫组化SP法检测116例肺癌患者组织中突变型p53和Cox-2蛋白表达水平,并用CD34标记血管来计数肿瘤组织的微血管密度。结果116例肺癌中,突变型p53蛋白阳性47例(40.52%),Cox-2蛋白阳性78例(67.24%)。Cox-2蛋白的表达与肿瘤TNM分期(P=0.014)及其中的淋巴结转移情况(P=0.006)密切相关,且阳性表达的肺癌组织中微血管密度明显高于阴性表达者(P=0.000),有统计学意义。COX模型多因素分析显示,淋巴结的转移(P=0.004)和Cox-2蛋白的阳性表达(P=0.000)是肺癌患者的预后不良因素。结论突变型p53与Cox-2蛋白的表达有关,Cox-2可作为判断肺癌患者预后不良的潜在指标。Purpose To investigate the prognostic significance and association of the expression of mutated p53 with Cox-2 protein in lung caneer. Methods The positive expression of mutated p53, Cox-2 and CD34 protein were observed and the microvascular density was evaluated in 116 cases of the tumor. Results Immunohistochemical staining showed that the positive rate of mutated p53 and Cox- 2 protein expression were 47 cases （40. 52% ） and 78 cases（67.24% ） of lung cancer. Expression of Cox-2 was related to tumor TNM staging（P =0. 014）and lymph nodes metastasis （P = 0. 006）, and that microvascular density in the cases of positive expression was significantly higher than that negative expression （ P = 0. 000 ）. The COX model showed that lymph nodes metastasis （ P = 0. 004 ） and the positive rates of Cox-2 protein（ P = 0. 000）were factors related to poor prognosis in patients with lung cancer. Conclusion Mutated p.53 protein can improve the expression of Cox-2, which can serve as a potential marker of prognosis in lung cancer.

关 键 词：肺肿瘤 P53 COX-2 CD34 预后 

分 类 号：R734.2[医药卫生—肿瘤]