胃肠道平滑肌起搏电流产生机制的研究进展  

Progress of research on the mechanism of pacemaker currents generated by gastrointestinal smooth muscle

作　　者：张扬[1] 韩燕飞[1] 许文燮[1] 

机构地区：[1]上海交通大学医学院生理学教研室,上海市200240

出　　处：《世界华人消化杂志》2007年第27期2875-2879,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金;No.30360031~~

摘　　要：越来越多的研究结果表明,Cajal间质细胞是胃肠道平滑肌慢波电位和自发性节律性收缩活动的起搏细胞.关于Cajal间质细胞起搏电流产生机制的研究近来进展很快,但仍存在一些分歧.本文就目前关于起搏电流的产生及传播机制的研究进展作一综述.More and more evidence indicates that interstitial cells of Cajal are pacemaker cells that generate slow waves and spontaneous rhythmic contractions in the gastrointestinal tract. Although research on the pacemaking mechanism has progressed rapidly, there are some differing results. This paper reviews research progress of the mechanism of pacemaker currents and their propagation.

关 键 词：CAJAL间质细胞 起搏电流 非选择性阳离 子通道 IP3介导的钙释放 线粒体 

分 类 号：R57[医药卫生—消化系统]