肝星状细胞及相关细胞因子在肝纤维化形成中的作用  

Role of hepatic stellate cells and correlated cytokines in the formation of hepatic fibrosis

作　　者：杨悦杰[1] 黄芬[1] 

机构地区：[1]中国医科大学附属盛京医院感染科,辽宁省沈阳市110004

出　　处：《世界华人消化杂志》2007年第27期2885-2890,共6页World Chinese Journal of Digestology

摘　　要：肝纤维化(hepatic fibrosis)是指肝脏内弥漫性细胞外基质(extracellular matrix,ECM)过度沉积的病理过程.肝星状细胞(hepatic stellate cells,HSC)被认为是ECM的主要来源细胞,在肝纤维化发生发展中起着关键作用.另外,各种病因引起肝细胞损伤时,Kupffers细胞(KF),肝窦内皮细胞等分泌一系列细胞因子,通过旁分泌和自分泌方式作用于邻近的HSC,影响其增殖,趋化和ECM代谢.因此,HSC及细胞因子与肝纤维化的发生发展关系极为密切,阐明其关系,有助于以HSC为靶点的肝纤维化方面的研究,现就其关系分别综述如下.Hepatic fibrosis is a pathological process with excessive deposition of extracellular matrix （ECM） throughout the liver. Hepatic stellate cells （HSCs） are thought to be a major source of ECM and play a critical role in the process of hepatic fibrosis. In addition, when various pathogenic changes lead to hepatocyte damage, Kupffer＇s cells and liver sinus endothelial cells, among others, excrete a series of cytokines. These affect adjacent HSCs in a paracrine and autocrine manner, which influences the proliferation and inversion of HSCs and the metabolism of ECM. Therefore, there is a very close relationship between HSCs, cytokines and fibrosis. Elucidating the course of hepatic this relationship will benefit research on the role of HSCs in hepatic fibrosis.

关 键 词：肝星状细胞 细胞因子 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]