急性脑出血后早期抗自由基治疗临床观察  

Clinical Observation of the Early Treatment of Acute Cerebral Hemorrhage with Free Radical Scavenger

作　　者：卢正娟[1] 王幸[1] 沈莉[1] 徐运[1] 

机构地区：[1]南京大学医学院附属鼓楼医院神经内科,江苏南京210008

出　　处：《医学临床研究》2007年第10期1685-1686,共2页Journal of Clinical Research

摘　　要：【目的】观察急性脑出血后早期抗自由基治疗的临床效果。【方法】将59例脑出血患者随机均分为治疗组和对照组。治疗组在常规治疗的基础上,给予自由基清除剂依达拉奉30 mg+生理盐水100 mL静脉滴注,30 min内滴完,每日2次,共14 d。治疗组于治疗前及治疗后d14分别进行神经功能缺损评分及疗效评定。【结果】治疗14d后,治疗组神经功能缺损评分为(85.8±17.1)分,明显高于对照组的(68.7±22.7)分(P<0.05);治疗组的显效率和有效率分别为(33.3%)和(66.7%),显著高于对照组的(10.2%)和(44.7%)(P<0.05)。【结论】急性脑出血后早期给予抗自由基治疗可促进脑出血患者的神经功能康复,改善神经功能缺损症状。[Objective]To evaluate the clinical efficacy of free radical scavenger on the early treatment of acute cerebral hemorrhage. [Methods]Fifty nine cases of acute cerebral hemorrhage were divided into treatment group and control group randomly. The patients in treatment group were injected intravenously twice daily with 30 mg edaravone for 14 days. Meantime, routine treatment for acute cerebral hemorrhage was carried on. The same treatment except injection with edaravone was implemented in the control group. Neurological functional deficit scores were utilized for assessment before treatment. On the 14th day after treatment , the patients were assessed again and the efficacy was recorded. [Results]After 14 days treatment , the neurological functional deficit scores of treated group were 85.8± 17. 1 , whereas those of the control group were 68.7± 22.7. There was significant difference between two groups （ P 〈0.05） . There were also significant differences between two groups in terms of apparent effect rate （33.3 % in treated group and 10.2% in control group, P 〈0.05） and improvement rate （66. 7 % in treated group, 44.7 % in control group, P 〈0.05）. [Conclusion]Free radical scavenger can accelerate the recovery of neural function after acute cerebral hemorrhage.

关 键 词：脑出血/治疗 急性病 自由基清除剂/治疗应用 

分 类 号：R743.34[医药卫生—神经病学与精神病学]