丝裂霉素C诱发绒毛膜癌患者及正常人淋巴细胞姐妹染色单体互换的研究  

Spontaneous and Mitomycin C Induced Sister Chromatid Exchang in Choriocarcinoma Patients and Normal Individuals

作　　者：徐昌芬[1] 周亚东[1] 朱启锭[1] 吴瑞娟[1] 葛百明 

机构地区：[1]南京医科大学组织胚胎学教研室

出　　处：《南京医科大学学报（自然科学版）》1997年第4期315-318,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：对３０例绒毛膜癌患者及３０例正常妇女进行自发姐妹染色单体互换（ＳＣＥ）及丝裂霉素Ｃ（ＭＭＣ）诱发ＳＣＥ率的研究，分析了绒毛膜癌患者及正常人不同年龄组淋巴细胞ＳＣＥ率的变化。结果表明：①不同年龄组自发及ＭＭＣ诱发ＳＣＥ率无明显差异，ＳＣＥ率的变化不受年龄因素的影响。②绒毛膜癌患者自发及诱发ＳＣＥ率明显增高，自发ＳＣＥ率为（７．２８±０．３４）；诱发ＳＣＥ率为（１３．９６±０．２６），ＳＣＥ未回复率是正常对照组的２．０倍。ＳＣＥ未回复率越高，ＤＮＡ损伤后修复能力越差。To investigate the relationship of DNA repair level with age and choriocarcinoma, we studied the frequency of spontaneous sister chromatid exchange(SCE) and Mitomycin C(MMC) induced SCE (recovering SCE) in 30 patients with choriocarcinoma and 30 normal women. The results showed that the spontaneous and recovering SCE frequency were not influenced by age. In choriocarcinoma patients they were significently higher than those in controls( P <0.001), indicating the capacity and potentiality of DNA repair in patients are depressed. In choriocarcinoma patients, the spontaneous SCE was (7.28±0.34), induced SCE (13.96±0.26), nonrecovering ratio of SCE was twice as high as that in control, changes of nonrecovering ratio of SCE run in parallel with the supression of DNA repair capacity.

关 键 词：DNA损伤 绒毛膜肿瘤 丝裂霉素C 

分 类 号：R737.330.2[医药卫生—肿瘤]