2005年中国医院知识仓库收载的药物配伍稳定性文章的调查分析  

Retrospective Analysis of Literature on Compatible Stability of Drugs Indexed in CHKD in 2005

作　　者：郑志昌[1] 谭蓉[1] 

机构地区：[1]贵阳医学院附属医院,贵阳市550004

出　　处：《中国药房》2007年第31期2477-2478,共2页China Pharmacy

摘　　要：目的:了解我国药物配伍稳定性方面研究的总体情况。方法:通过中国医院知识仓库检索,将2005年52种期刊上发表的113篇药物配伍稳定性文章进行归纳分析。结果:涉及药物类别主要为抗生素(59%)、中药或中药成分(20%)及其它药物(21%) ;91篇文章进行了定量分析,主要方法为紫外分光光度法(79%)、高效液相色谱法(20%)。结论:紫外分析方法的大量采用及试验方案设计不够严谨,可能会严重影响结果的准确性,给临床安全配伍用药留下极大隐患。OBJECTIVE： To probe into the overall situation about the study on compatible stability of drugs. METHODS： The compatible stability of drugs reported in a total of 113 articles in 2005 in 52 kinds of periodicals were retrieved from CHKD and summarized analytically. RESULTS： The drug categories involved were chiefly antibiotics （59%）, Chinese traditional medicines or Chinese drug components （20%） and other drugs （21%） . Quantitative analyses in 91 articles were chiefly conducted by ultraviolet spectrophotometry （79%） or HPLC （20%）. CONCLUSION： Because the ultraviolet spectrophotometry was greatly used and some experimental designs were not well- knit enough, the reliability of experimental results of compatible stability of drugs might be seriously affected, which poses a great danger to the clinical compatible use of drugs.

关 键 词：中国医院知识仓库 药物配伍 稳定性 分析 

分 类 号：R914.1[医药卫生—药物化学]