胃癌组织中ILK、PTEN蛋白表达的意义  

Expression of ILK and PTEN in gastric cancer tissue

作　　者：王舟[1] 王学春[1] 李继锋[2] 孙锡超[3] 王旭[1] 

机构地区：[1]济宁医学院,山东济宁272013 [2]济宁医学院附属医院 [3]济宁市第一人民医院

出　　处：《山东医药》2007年第31期24-26,共3页Shandong Medical Journal

基　　金：山东省卫生科学技术发展计划项目(2003HW015)

摘　　要：目的探讨整合素连接激酶(ILK)在胃癌发生发展过程中的作用及与抑癌基因PTEN的关系。方法采用免疫组化法和原位杂交法对112例胃癌及76例正常胃黏膜组织ILK和PTEN蛋白、PTEN mRNA进行检测。结果胃癌组与正常胃黏膜组、胃癌浸润超过肌层组和未超过肌层组、胃癌有淋巴结转移组和无淋巴结转移组之间ILK、PTEN蛋白表达强度比较差异均有统计学意义(P<0.05或<0.01)。胃癌组PTEN mRNA表达明显低于正常胃黏膜组(P<0.01)。ILK与PTEN蛋白表达强度呈负相关(r=-0.347,P<0.01)。结论胃癌的发生发展过程中伴随着ILK蛋白表达的增强及PTEN蛋白表达的减弱或消失,控制ILK和PTEN蛋白有望成为胃癌治疗的新靶点。[ Objective] To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN. [ Methods] ILK and PTEN proteins,PTEN mRNA of 76 cases of normal gastric mucosa and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization. [ Results ] The expression of ILK,PTEN protein in gastric carcinoma group and normal gastric mucosa group, muscular layer invasive group and no muscular layer invasive group, lymphatic metastasis group and non-lymphatlc metastasis group were all statistical significance（ P 〈 0.05 or 〈 0.01 ） , The expression of PTEN mRNA of gastric carcinoma group was lower than that of the normal gastric mucosa group （ P 〈 0.01 ）. The expression of ILK and PTEN protein had negative correlation （ r = - 0.347,P 〈 0.01 ）. [ Conclusion ] ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and development of gastric carcinoma, and Controling them may become a new treating target of gastric cancer.

关 键 词：整合素连接激酶 PTEN 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]