RUNX3基因失活与胃癌变  

Inactivation of the RUNX3 Gene and Gastric Cancer Carcinogenesis

作　　者：余燕民[1] 李小英[1] 许洪卫[1] 

机构地区：[1]上海市第十人民医院普外科,上海市200072

出　　处：《中国肿瘤临床》2007年第20期1190-1192,1196,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:39570786)

摘　　要：RUNX3基因是新近发现的一种抑癌基因,属人runt相关转录因子(human runt-related transcription fac-tor,RUNX)家族成员,是TGF-β信号传导通路中的一个重要环节,杂合子丢失(LOH)和启动子高甲基化可使其失活,并可导致胃癌的发生、发展和转移。本文综述了RUNX3基因的结构、功能及其与胃粘膜异常增生与癌变的关系。As one of the human runt-related transcription factors, the RUNX3 gene is found to be an anti-oncogene. It plays an important role in the TGF-β signaling pathway. The mechanism of RUNX3 inactivation involves loss of heterozygosity （LOH） and promoter hypermethylation, resulting in the development and metastasis of gastric cancer. The structure and function of RUNX3 and the relationship between the RUNX3 gene and gastric mucous hyperplasia as well as gastric cancer are reviewed in the article.

关 键 词：RUNX3 TGF-Β 胃粘膜异常增生 胃癌 胃癌转移 

分 类 号：R735.2[医药卫生—肿瘤]