肝宁颗粒剂中川芎的提取和干燥工艺研究  

Study on extraction and drying of ligusticum chuanxiong in Gan-ning Granule

作　　者：丁原全[1] 万绍晖[2] 许启泰[2] 康廷国[3] 

机构地区：[1]沈阳军区卫生技术干部训练中心,辽宁大连116017 [2]河南大学药学院,河南开封475001 [3]辽宁中医药大学,辽宁沈阳110032

出　　处：《中国中药杂志》2007年第21期2244-2246,共3页China Journal of Chinese Materia Medica

摘　　要：目的:优选肝宁颗粒剂中川芎的最佳提取工艺,并对提取液的浓缩及干燥方式进行考察。方法:以阿魏酸为评价指标,采用正交试验设计,对80%乙醇用量、提取次数和回流时间进行优选;采用正交试验设计,对喷雾干燥的进样速度、进风口温度和药液相对密度进行优选。结果:80%乙醇用量10倍、回流提取3次、每次1 h的提取工艺较为合适,其中提取次数为主要影响因素;喷雾干燥药液相对密度为1.15、进风口温度为120℃、流速为8.5mL.min-1较为合适,其中进样速度为主要影响因素。结论:该提取工艺和喷雾干燥工艺所得产品中阿魏酸的含量较高,为川芎药材中阿魏酸的提取和干燥方式奠定了实验基础。Objective： To find out the optimum extract process for Ligusticum chuanxiong in Gan-ning Granule, and studyed the methods of concentration and dry for the extract. Method： With the yield of ferulic acid as the assessment index, to optimize the 80% alcohol totalling, extracting times and circumfluence time for extract process by the orthogonal design, to optimize the inlet-air temperature, feed speed and density of feed for spry drying by the orthogonal design. Result： The optimum procedure was the ferulic acid were extracted for 1 hour with 3 times of 80% alcohol. While extracting times effected it most porminently. The optimal processing conditions of spry drying were inlet-air temperature 120 ℃, feed speed 8. 5 mL · min^-1 and density of feed 1.15, While feed speed effected it most porminently. Conclusion： The experimental results provide the basis for the extraction process and drying process of the ferulic acid in ligusticum chuanxiong.

关 键 词：川芎 正交试验设计 提取工艺 喷雾干燥工艺 阿魏酸 HPLC 

分 类 号：TQ461[化学工程—制药化工]