湖北栝楼种子中不皂化物质的化学成分研究  

Chemical constituents in unsaponifiable matter from seeds of Trichosanthes hupehensis

作　　者：郗砚彬[1] 巢志茂[2] 王金[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院医学实验中心,北京100700

出　　处：《中国中药杂志》2007年第21期2262-2265,共4页China Journal of Chinese Materia Medica

基　　金：国家人事部留学回国人员科技活动优秀类择优项目

摘　　要：目的:对湖北栝楼种子的不皂化部分进行化学成分研究。方法:石油醚提取脂肪油,氢氧化钾进行皂化反应,对不皂化部分进行硅胶色谱的分离和纯化,用MS,IR,1H-NMR和13C-NMR波谱技术进行化合物的结构鉴定。结果:分离获得并鉴定了9个化合物,分别为栝楼仁二醇(1),异栝楼仁二醇(2),5-脱氢栝楼仁二醇(3),7-氧代二氢栝楼仁二醇(4),豆甾-7-烯-3β-醇(5),豆甾-7,22-二烯-3β-醇(6),10α-葫芦二烯醇(7),β-谷甾醇(8),豆甾-7,22-二烯-3β-O-β-D-葡萄糖苷(9)。结论:这些化合物均为首次从该植物分离获得。Objective： To study the chemical constituents of unsaponifiable matter from the seed oil of Trichosanthes hupehensis. Method： The fatty oil from the seeds of T. hupehensis was extracted with petroleum ether. The saponification was carried out with potassium hydroxide. The unsaponifiable matter was isolated and purified by silica gel column chromatography. Their structures were elucidated by means of MS, IR, UV, and ^1H-NMR. Result： Karounidiol, isokarounidiol, 5-dehydrokarounidiol, 7-oxodihydrokarounidiol, stigmast-7-en-3β-ol, stigmast-7, 22-dien-3β-ol, 10α-Cucurbitadienol, β-sitosterol, stigmast-7, 22-dien-3β-O-β-D-glucoside were elucidated. Conclusion： All of these compounds were found in this plant for the first time.

关 键 词：湖北栝楼 栝楼仁二醇 10α-葫芦二烯醇 不皂化物 五环三萜 

分 类 号：R284.1[医药卫生—中药学]