CT介导下经皮盐酸注射疗法原位灭活原发性肝癌的临床研究  

Clinical study of CT mediated percutaneous hydrochloric acid injection in situ destructive therapy for primary liver cancer

作　　者：冯威健[1] 韩素红[2] 刘赞[2] 周蕾[1] 赵艳杰[1] 曹艺[1] 张红梅[1] 姜妮[1] 

机构地区：[1]北京世纪坛医院北京大学第九临床医学院肿瘤内科,北京100038 [2]河北医科大学研究生院,050017

出　　处：《临床肿瘤学杂志》2007年第10期759-762,共4页Chinese Clinical Oncology

基　　金：首都医学发展科研基金项目(2002-3056)

摘　　要：目的:探讨CT介导经皮盐酸注射疗法对肝癌的原位灭活作用与临床安全性。方法:应用CT介导下经皮穿刺对原发性肝癌35例48个瘤灶内注射含6mol/L盐酸的注射液,观察原位灭活率、影像学组织学变化、远期生存率和不良反应。结果:CT扫描显示肿瘤呈低密度改变,肿瘤血管消失,PET检查肿瘤失去代谢,穿刺活检全部为坏死组织,肿瘤坏死彻底,AFP降低;全组35例患者均随访,1年生存率为100%,2年生存率为91%,3年生存率为64%,其中3例生存超过4年。死亡原因主要是其他部位的复发转移。主要的不良反应包括轻度疼痛、低热。结论:CT介导下经皮盐酸注射疗法治疗肝癌可原位灭活癌组织,是非手术局部治疗肝癌的新方法,值得进一步研究。Objective：To evaluate in situ destructive effects and safety of CT mediated percutaneous hydrochloric acid injection therapy for liver cancer. Methods：Guidance and monitored by CT slice simulation puncture technique, 35 patients with 48 malignant lesions of primary liver cancer were treated intratumor injection of a protein destructive agent contained 6mol/L hydrochloric acid. The in situ destructive rate, imaging and histopathology evaluation, survival rate and side effects were observed. Results：A low density and no enhancement of tumor by CT scan were shown. A well necrosis and destructive rate of cancer was obtained by PET, biopsy and AFP measurement. The overall 1-, 2-, and 3-year survival rates were 100% ,91% and 64%, respectively. Three cases of all patients had survived over 4 years. The reason of death was recurrence and metastasis. No changes of hart, liver and kidney function were fund. Mean side effects were slight pain, lower fever and so on. Conclusion： CT mediated percutaneous hydrochloric acid injection therapy （PHAIT） shown well in situ destructive effects and was a new method for percutaneous treatment of the liver cancer.

关 键 词：经皮盐酸注射疗法 蛋白灭活剂 原位灭活 肿瘤/治疗 

分 类 号：R730.53[医药卫生—肿瘤] R735.7[医药卫生—临床医学]