骨髓干细胞诱导分化为肝系细胞的研究进展  

Advances in the hepatocyte lineage induced by differentiation of bone marrow stem cells

作　　者：李俊峰[1] 马勇[2] 严家春[2] 

机构地区：[1]安徽医科大学临床药理研究所,安徽合肥230032 [2]中国人民解放军第123医院肝病中心实验室,安徽蚌埠233015

出　　处：《世界感染杂志》2007年第5期362-366,共5页World Journal of Infection

摘　　要：骨髓干细胞（bone marrow stem cells，BMSC）因其具有自我更新能力和发育的多能性，成为当前医学研究的热点。BMSC是目前研究较多的一类成体干细胞，主要有造血干细胞和间充质干细胞两大类．BMSC不但可以自发分化，而且在诱导因素作用下可以分化为多种组织细胞，如神经细胞、骨骼肌细胞、心肌细胞、肝系细胞等。因此，BMSC在细胞移植学、疾病治疗学等领域有着广阔的应用前景。本文主要对BMSC诱导分化为肝系细胞的研究进行综述。Bone marrow stem cells （BMSCs） has self-renewal capability and developmental pluripotency, which makes it a hot spot of current medical research. At present, BMSCs is an important adult stem cell including hematopoietic stem cells and mesenchymal stem cells. BMSCs could differentiate spontaneously, while it also could differentiate into many kinds of tissue cells under certain induction, such as nerve cell, skeletal muscle cell, cardiac muscle cell, hepatic lineage cell, etc. Therefore, BMSCs might be used in many fields such as cell transplantation, disease therapeutics and so on. This review summarizes the advances in the hepatocyte lineage induced by differentiation of bone marrow stem cells.

关 键 词：骨髓细胞 造血干细胞 间充质干细胞 肝/细胞学 细胞分化 

分 类 号：R575.1[医药卫生—消化系统]