小儿肝母细胞瘤临床病理与预后因素的研究  

THE CLINICOPATHOLOGY AND PROGNOSTICFACTORS OF STUDY ON HEPATOBLASTOMA ININFANCY AND CHILDHOOD

作　　者：王绪洲[1] 周志强[1] 王敏[1] 

机构地区：[1]山东医科大学病理学教研室,济西铁路医院

出　　处：《山东医科大学学报》1997年第2期98-101,共4页Acta Academiae Medicinae Shandong

摘　　要：对２３例小儿肝母细胞瘤的临床病理学进行了研究，并分析了病理学改变与预后的关系。本组肿瘤均为手术切除标本，用组织化学ＨＥ染色和免疫组化ＡＦＰ检测。结果表明，该肿瘤病理形态特点为瘤体大，最大直径４５ｃｍ；主要成分为胚胎性肝上皮组织，部分病例有胚胎性或较成熟的间叶组织。肿瘤发生在肝左叶或边缘部者预后较好，瘤体大或多结节型者预后差；胎儿型和混合型预后好，未分化型预后差；肝脏血液循环丰富，肝母细胞瘤生长速度快，易侵袭破坏血管发生血行转移，这是影响其预后的重要因素。To analyse the relationship between the pathological changes and the prognosis of hepatoblastoma through the pathological study on 23 cases of hepatoblastoma in infancy and childhood. Twenty-three hepatoblastomas were surgical specimens. The study was performed by using the common and immunohistochemical stainings. The morphologic features were , 1. the tumors are larger in size , the maximum being 45 cm in diameter; 2. the main elements were embryonic epithelial tissues of the liver , and immature mesenchymal tissues in some of the tumors. The clinicopathological observations show that the main factors affecting the prognosis include location , size , type and biological behavior of the tumor. The prognosis of tumors in the left lobe or on the edge of the liver is favorable , and that of large tumors and tumors with multiple nodules is unfavorable. The prognosis of fetal and mixed type one. is good , and that of undifferentiated type tumors is poor. The biological behavior. of hepatoblastomas shows the rapid growth of the tumors as a result of the massive blood circulation in the liver and the consequent vascular invasion presented metastatic growths that is the most important factor effecting the prognosis

关 键 词：肝肿瘤 病理学 预后 婴儿 儿童 肝母细胞瘤 

分 类 号：R735.702[医药卫生—肿瘤] R730.7[医药卫生—临床医学]