细胞色素CYP450 2E1基因Ras Ⅰ/Pst Ⅰ位点多态性与肺癌易感性的系统评价  

Systematic review of the relationship between genetic polymorphism of cytochrome P450 2E1 at Ras Ⅰ/Pst Ⅰ loci and the susceptibility to lung cancer

作　　者：谢瑞莲[1] 管晓翔[1] 陈龙邦[1] 王靖华[1] 刘全俊[2] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院肿瘤内科,江苏南京210002 [2]东南大学分子与生物电子学国家重点实验室,江苏南京210096

出　　处：《南京医科大学学报（自然科学版）》2007年第9期911-915,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30470669)

摘　　要：目的:利用Meta分析的方法系统评价细胞色素CYP450 2E1基因RasⅠ/PstⅠ位点多态性与肺癌易感性的关系。方法:检索1991～2006年Cochrane图书馆、Medline、Elsevier、Ovid、Highwire Press、西文生物医学期刊文献数据库、中国期刊网、中国生物医学文献数据库、维普科技期刊全文数据库等,语种不限,获取有关细胞色素CYP2E1基因RsaⅠ/PstⅠ位点多态性与肺癌易感性的关系的研究结果,以病例组与对照组CYP2E1基因型分布的比值比(OR)为效应指标,确定纳入标准,对文献进行评价筛选,异质性检验,然后利用RevMan4.2软件对各研究原始结果进行统计处理,并计算合并OR值及其95%可信区间。结果:按照纳入标准,最终入选文献共有9篇病例对照研究,累计病例1123例,对照1434例,Meta分析结果合OR值为1.55,95%可信区间为1.30～1.86,Z值为4.84,说明细胞色素CYP450 2E1基因型频率分布与肺癌的关联有统计学意义。单纯病例研究分析示吸烟与CYP450 2E1c1/c1基因型交互作用OR值为0.73,95%可信区间是0.45～1.15,Z值为1.37,说明吸烟与CYP450 2E1c1/c1基因型之间交互作用无统计学意义。结论:对目前相关研究结果的Meta分析显示CYP2E1基因多态性与肺癌易感性之间存在一定相关性,即携带RasⅠ/PstⅠ野生型CYP2E1基因纯合子的个体发生肺癌的危险性较高,但与吸烟的交互作用尚不确定。Objective：To evaluate relationship between polymorphisms of cytochrome P4502E1 at RasⅠ/PstⅠ loci and susceptibity to lung cancer by means of Meta-analysis. Methods：Studies from 1991-2007 were retrieved through Cochrane Library,Medline,Elsevier,Ovid,Highwire Press,EMCC,CNKI,CBMdisk and VIP database without language limitation to collect relevant papers. Odds ratio of CYP2E1 genotype distributions in the group of patients with lung cancer and the group of healthy control was calculated. The Meta-analysis was applied with RevMan 4.2 software for heterogereity test and pooled OR calculation. Results：Nine case-control studies with 1 123 cases and 1 434 controls were analysed by fixed-effect meta-analysis method. The pooled odds ratio of CYP2E1 genotype c1/c1 vs c1/c2 ＋c2/c2 was 1.55（95%CI：1.30～1.86）,Z statistics were 4.84. An association between CYP2E1 c1/c1 genotype and smoking was not found among cases. The pooled OR of interaction was 0.73（95%CI：0.45～1.15）. Z statistics were 1.37. Conclusion：There was enough evidence currently to prove the relationship between CYP2E1 genetic polymorphism and susceptibility to lung cancer. It was demonstrated that the genetic polymorphism of CYP2E1 at RasⅠ/PstⅠ loci was the important risk factor for the susceptibility to human lung cancer, but there was not a definite interaction between the effects of smoking and CYP2E1 c1/c1 genotype on lung cancer risk.

关 键 词：肺癌 细胞色素P450 多态性 比值比 Meta分析 吸烟 

分 类 号：R734.2[医药卫生—肿瘤]