门静脉动脉化对肝硬化犬部分肝切除后门静脉血流动力学的影响  

Study of the effect of portal vein arterialization on the changes of hemodynamics of portal veins in dogs

作　　者：王鹏[1] 李鹏[1] 芮理[1] 李厚祥[1] 

机构地区：[1]南通大学附属医院普外科,江苏226001

出　　处：《交通医学》2007年第5期487-488,共2页Medical Journal of Communications

基　　金：南通市社会发展科技计划(S30003)

摘　　要：目的:旨在研究门静脉动脉化(portal veinarteri alization,PVA)对肝硬化犬部分肝切除后门静脉血流动力学的影响,以探讨PVA的临床可行性。方法:肝硬化犬分为3组:A组(动脉化组)行肝左外叶切除加门静脉动脉化手术;B组(对照组)仅行肝左外叶切除手术;C组(假手术组)。每组均于术后4周处死,实验过程中检测门静脉压力的变化。结果:门静脉压力在术后即时A组为(19.71±1.20)cmH2O,B组为(11.72±0.58)cmH2O,两者差异有统计学意义(P<0.01),4周后A组降至(13.99±1.18)cmH2O,有明显下降趋势。结论:PVA未造成近期明显门静脉高压,有望成为临床上肝脏手术时预防肝衰竭、支撑肝功能的有效辅助手段。Objective： To study the effect of portal vein arterialization （PVA） on the changes of hemodynamics of portal veins in dogs,to provide a basis for its clinical use. Methods： The liver cirrhosis model of dogs was set up, the dogs were divided into three groups randomly; Group A （PVA group）：partial hepatectomy（42%）plus PVA was given; Group B （control group）：only partial hepatectomy （42%） was given; Group C （sham-operated group）; All dogs were killed at four weeks after operations. During the experiment, changes of hemodynamics of portal veins were observed. Results： Portal venous pressure （PVP） rose after operation and then declined significantly after four weeks.Conclusion： PVA has less effect on the change of PVP. So PVA could provide an auxiliary method to prevent liver failure and improve liver function in the operation of the liver.

关 键 词：门静脉动脉化 门静脉血流动力学 肝硬化犬 

分 类 号：R575.2[医药卫生—消化系统]