肺癌脑膜转移的临床诊断及治疗  

Clinical Diagnosis, Treatment Study of Meningitis Metastasis of Lung Cancer

作　　者：陶荣杰[1] 徐军[1] 王爽力[1] 陈增谦[1] 

机构地区：[1]山东省肿瘤医院,山东济南250117

出　　处：《中国神经肿瘤杂志》2007年第3期183-185,共3页Chinese Journal of Neuro-Oncology

摘　　要：背景与目的:肺癌脑转移发生率高,脑膜转移更为严重且预后差。本文总结我们收治的肺癌脑膜转移病例,分析临床诊断、治疗方法以及预后。方法:我科于2002年2月至2007年2月收治肺癌患者132例,肺癌脑膜转移17例,对17例肺癌脑膜转移的临床资料进行回顾性分析。结果:有明确影像诊断者17例,CSF细胞学诊断阳性6例,17例分别接受鞘内化疗、放疗和全身化疗等治疗,3例手术分流,总生存期为5周至18个月,中位生存期为7个月。结论:肺癌脑膜转移的诊断主要依靠CSF细胞学和MRI检查结果,治疗手段有鞘内化疗、局部放疗手术分流和全身化疗等。BACKGROUND ＆ OBJECTIVE：This paper was to review the clinical diagnosis, therapies and prognosis of meningeal metastases of lung cancer（LCMM）. METHODS： One hundred and thirty two cases with lung cancer were reviewed from Feb in 2000 to Feb in 2007. Seventeen patients were affected by meningeal metastasis. The clinical information of these 17 patients were retrospectively reviewed and analyzed. RESULTS： Among these 17 patients, LCMM was diagnosed by MRI scan in 17 cases and by cytological analysis of CSF in 6 patients. These patients received therapies including intrathecal chemotherapy, radiotherapy and systemic chemotherapy. The median survival was 7 months （range 5 weeks to 18 months）. CONCLUSIONS： LCMM can be diagnosed by MRI scan and CSF cytological analysis. It carries a poor prognosis despite therapies, including intrathecal chemotherapy, radiotherapy and systemic chemotherapy.

关 键 词：肺癌 脑膜转移瘤 诊断 治疗 

分 类 号：R739.41[医药卫生—肿瘤]