羟基喜树硷联合醛氢叶酸、5-氟脲嘧啶和/或顺铂治疗晚期胃癌36例的疗效观察  

Clinlcal Research of HCPT in Combination with LV+5Fn+/-DDP Regimen in treatment of advanced Gastric Cancer

作　　者：吴紫华[1] 

机构地区：[1]安徽省巢湖市第二人民医院,安徽巢湖238000

出　　处：《海南医学》2007年第11期18-19,共2页Hainan Medical Journal

摘　　要：目的观察含羟基喜树硷联合化疗方案治疗晚期胃癌的近期疗效及不良反应。方法29例,HCPT6mg/m2,静滴,1～5月,醛氢叶酸100mg/m2。静滴第1～5月;1—氟脲嘧啶400mg/m2,静滴第1～5月,顺铂(DDP)40mg,第1～3天,DDP应水化;7例因胃肠道反应未用DDP外余同上,3～4周为一个周期。结果36例中,总有效率(CR+PR)为50%(18/36)主要不良反应为血液学毒性,及恶心呕吐等。结论含羟基喜树硷的CFH/CFHP方案是治疗晚期胃癌有效且毒性较小的化疗方案。Objective To observe the effects and adverse reaction of regimen involved HCPT for patients with advanced gastric cancer. Methods 29 cases of advanced gastic cancer were treated with CF 100mg/m^2 dayl-5, 5-Eluorouracil 400mg/m^2 dayl-5, HCPT 6mg/m^2 dayl-5, Cisplatin400mg/m^2 day1-3. 7 cases bssides DDP. Other is same, Repeat every3--4 weeks. Results Overall response rates （CR＋PR）were 50%, the major ad- verse raction are mild hematology toxicity. Nausea and vomiting. Conclusions regimen involved HCPT is an effective and mild toxicity. Comdined chemotherapy for advanced gastric cancer.

关 键 词：羟基喜树硷 醛氢叶酸 5—氟脲嘧啶 晚期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]