蛋白多肽类药物体内动力学分析方法的研究新进展  

Recent Progress in the Study on the Analytical Method of Protein Polypeptide Drug harmacokinetics

作　　者：方春生[1] 顾月清[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009

出　　处：《药学进展》2007年第10期433-438,共6页Progress in Pharmaceutical Sciences

摘　　要：蛋白多肽类药物由于其在生物体内含量低、半衰期短和易受内源性物质干扰等特点而使其体内动力学的研究面临很多挑战。生物样品分析方法是进行药物体内动力学研究的基础。综述了研究蛋白多肽类药物体内动力学的常规分析方法:免疫学分析法、同位素标记示踪法、生物检定法和理化分析技术。展望了荧光标记近红外检测技术在蛋白多肽类药物体内动力学无损实时在位分析上的应用前景。Kinetics studies of protein polypeptide drugs face many challenges because of their low content in organisms, short half-life and vulnerability to interference by endogenous substances. Biological sample arialyrical methods am the basis of pharmacokinetics research. The cormaonly used analytical methods by which we study protein peptide pharmacokinetics, such as immtmoassay, isotope label trace assay, bioassays and physicochemical analytical techniques were summarized. And the prospect of near-infrared fluorescent detection technology in nondestructive real-time analysis of protein and pepfide drugs in vivo kinetics were mentioned.

关 键 词：蛋白多肽类药物 体内动力学 分析方法 荧光标记近红外检测技术 

分 类 号：R969[医药卫生—药理学]