黄芪配伍当归对气虚血瘀模型大鼠血管内皮和肝窦内皮细胞CD54表达的影响  

Influence of Astragalus combined with Angelica on expressionof CD54 in endothelial cells of vessels and hepatic sinusoid in Qi-Deficiency and Blood-Stasis(气虚血瘀) Model rats

作　　者：王惠[1] 于丽秋[1] 韩冰[1] 滕佳林[1] 贾建昌[1] 

机构地区：[1]山东中医药大学肿瘤实验室,济南250014

出　　处：《中药药理与临床》2007年第5期39-41,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:探讨黄芪配伍当归(QG)对气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞CD54表达的影响。方法:用饥饿+游泳制造"气虚血瘀"大鼠模型,灌胃给药15d后测定心肺血管内皮和肝窦内皮细胞CD54的表达。结果:气虚血瘀模型大鼠心肺血管内皮和肝窦内皮细胞CD54的表达明显增高,QG能显著降低其过度表达。结论:QG益气活血作用与降低心肺血管内皮和肝窦内皮细胞CD54的过度表达有关。Objective： To investigate the influence of Astragalus membranaceus combined with Angelica sinensis （QG for short） on the expression of CD54 in vessels endothelial cells（VECs） and hepatic sinusoid endothelial cells（HSECs） of Qi - Deficiency and Blood - Stasis model rats. Methods： Using the method of hunger and fatigue to establish Qi - Deficiency and Blood - Stasis model rats, measuring the expression of CD54 in VECs and HSECs after ig administrate for 15d. Results： The expression of CD54 in VECs and HSECs of Qi - Deficiency and Blood - Stasis model rats markably raised, QG can effectively decrease their excessive expression. Conclusion ： Inhibiting the excessive expression of CD54 in VECs and HSECs may be one of the molecular mechanism of Replenishing Qi and Promoting Blood Circulation of QG.

关 键 词：芪归药对 血管内皮细胞 肝窦内皮细胞 CD54 

分 类 号：R285.5[医药卫生—中药学]