supported by the National Key R&D Program ofChina(Nos.2020YFA0803200,2017YFA0504504,and 2018YFA0107500);National Natural Science Foundation of China Grants(Nos.82003014,82150112,81725014,92168116,31930026,81972599,82173276,81822035);the Key Program for Basic Research of Shanghai(No.19JC1415600);Shanghai Rising-Star Program(Nos.22QA1407200,22QA1407300);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(No.SKLGE2103);the China Postdoctoral Science Foundation(No.2020M671231).
As an important part of tumor microenvironment,neutrophils are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis.Here we defined,at single-cell resolution,CD44-CxCR2-neutrophils as tumor-spe...