辣椒提取物对3种异嗜高岭土模型大鼠的止呕作用  

Antiemetic effects of extract of capsicum on emesis in three rat models of kaolin pica

作　　者：杨志宏[1] 赵德雪[1] 侯海燕 王心慧[1] 张芳[1] 岳旺[1] 

机构地区：[1]青岛大学医学院药学系,青岛266021 [2]山东省省立医院,济南250000

出　　处：《中国新药杂志》2007年第20期1682-1685,共4页Chinese Journal of New Drugs

摘　　要：目的:研究辣椒提取物(extract of capsicum,以下简称EC,含辣椒素10 mg·mL^(-1))对大鼠的止呕作用。方法:大鼠分别给予顺铂、阿朴吗啡及接受旋转刺激,建立大鼠异嗜高岭土的3种呕吐模型,观察EC预防给药对3种模型大鼠的止呕作用。结果:顺铂(3 mg·kg^(-1),ip)、阿朴吗啡(3.2 mg·kg^(-1),sc)以及旋转刺激(100 r·min^(-1),1 h)均能引起大鼠的异嗜呕吐行为,可作为建立大鼠异嗜高岭土模型的致呕最适剂量。EC 30,20,10 mg·kg^(-1)三个剂量组可抑制顺铂、阿朴吗啡、旋转所致的大鼠异嗜高岭土的量(P<0.05),并呈现一定的量效关系。结论:EC在大鼠异嗜呕吐模型上具有止呕作用,其机制可能与P物质及抑制呕吐中枢有关。Objective： To determine the antiemetic effects of extract of capsicum （EC, containing 10 mg·mL^-1 capsaicin） in rats. Methods： Rats were treated with cisplatin, apomorphine and rotation, respectively, and three emesis models of kaolin pica were induced to observe the antiemetic effects of pre-treatment with EC. Results： Emesis was successfully induced by cisplatin （3 mg·kg^-1, ip） , apomorphine （3.2mg·kg^-1, sc） and rotation （100 r·min^-1, 1 h）. EC at 10, 20, 30mg·kg^-1 inhibited kaolin intake induced by cisplatin, apomorphine and rotation in a dose-dependent manner （P 〈 0.05 ）. Conclusion： EC exhibits antiemetic effects in rats, which may be mediated by inhibiting P substance and the vomiting center in the central nervous system.

关 键 词：辣椒提取物 辣椒素 止呕 P物质 大鼠 

分 类 号：R285.5[医药卫生—中药学] R442.1[医药卫生—中医学]