伴破骨细胞样巨细胞的乳腺癌临床病理特征  

The clinicopathological features of mammary carcinoma with osteoclast-like giant cells

作　　者：王岩[1] 刘晓霞[1] 张少华[1] 马秀萍[1] 贾支红 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2007年第11期965-966,共2页Ningxia Medical Journal

摘　　要：目的探讨伴破骨细胞样巨细胞的乳腺癌(COGC)的临床病理学特征及鉴别诊断。方法对1例COGC进行病理形态学以及免疫组化分析。结果乳腺包块大体呈界限清楚的结节状,切面灰红、灰褐色,质细腻。镜下肿瘤主体为浸润性筛状癌。肿瘤有破骨细胞样巨细胞组成,大小形态各有差异,分布弥漫或不均匀,与肿瘤细胞关系密切。间质见不同程度的陈旧性出血,血管和纤维组织增生。免疫组化:破骨细胞样巨细胞CD68阳性,ac-tin、S-100蛋白、Cytokeratin(AE1/AE3)阴性。结论COGC是少见肿瘤,大体和组织学具有一定特点。Objective To explore the clinicopathological features and differential diagnosis of mammary carcinoma with osteoclast - like giant cells （COGC）. Methods One case of mammary carcinoma with osteoclast - like giant cells was investigated by morphological and immunohistochemistry test. Results Grossly, the tumor of the COGC was well circumscribed nodule with grey - red to brown color. Microscopically, the tumor parenchyma was invasive cribriform carcinoma. Osteoclastic giant cells varied in size and morphons, distributed diffusely, and it had close relationship with the tumor cells. Remote hemorrhage, asculare proliferation and fibrosis also could be seen in the stroma. Osteoclastic giant cells expressed CD68 but not S - 100 protein and actin and cytokeratin （AE1/AE3） performed immunohistochemical stain. Conclusion COGC is rare kind of tumor, and it has distinctive morphology.

关 键 词：乳腺肿瘤 破骨细胞样巨细胞 临床病理 

分 类 号：R737.9[医药卫生—肿瘤]