益肾疏肝法治疗抑郁症肾虚肝郁型的随机对照临床研究  

Tonify Kidney and Disperse the Depressed Liver-Energy to Treat the Depression of Renal Deficiency and Liver Stagnation Syndrome: A Randomized Controlled Clinical Study

作　　者：曲淼 唐启盛[1] 裴清华[1] 侯秀娟[2] 

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《中华中医药学刊》2007年第11期2343-2346,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：首都发展基金重大联合项目(03-I-02);北京中医药大学科研基金资助项目(20060203)

摘　　要：目的:探讨中药培元解忧方和西药氟西汀对抑郁症肾虚肝郁型患者的疗效,并对肾虚肝郁型的症状评定标准进行进一步验证。方法:在轻、中度抑郁症患者中,选取抑郁症肾虚肝郁型的患者,采取随机、对照、盲法的原则,对73例抑郁症患者进行中药培元解忧方和西药氟西汀的对照研究。使用证候研究中制订的《抑郁症肾虚肝郁证型症状评定表》和HAMD抑郁量表进行评定。结果:采用培元解忧方治疗轻、中度肾虚肝郁型抑郁症基本与氟西汀等效,6周观察结束时,二者HAMD总分无统计学差异(P>0.05)。但培元解忧方起效较氟西汀快,在2周时培元解忧方组的HAMD总分和因子分已明显下降(P<0.01),并且在胁肋胀痛,腰酸背痛等躯体症状和睡眠障碍的改善方面优于氟西汀。结论:培元解忧方治疗轻、中度肾虚肝郁型抑郁症基本与氟西汀等效。但是起效较氟西汀快,在躯体症状和睡眠障碍等改善方面优于氟西汀。Objective： To compare the efficacy of PeiYuan JieYou Decoction with fluoxetine on depression of renal de- ficiency and liver stagnation syndrome （ RDLS）, and to further validate the standards for RDLS symptom evaluation. Methods： 73 light and medium depression patients with RDLS syndrome had been randomized into two arms. Patients in the treatment arm were given PeiYuan JieYou Decoction and those in the controlled arm were given fluoxetine. All patients had scored with the TCM syndrome scale and the Hamilton depression scale. Results： There was no statistic difference in the results of Hamilton depression scale scoring between two arms（ P 〉 0.05 ）. However, PeiYuan JieYou Decoction was superior for the release of somnipathy and somatization such as distending pain at hypochondrium and pains at lumbar and back. Conclusion ： PeiYuan JieYou Decoction is equally effective to fluoxetine on light and medium depression of RDLS syndrome. However, it was superior for the release of somnipathy and somatizatlon.

关 键 词：肾虚肝郁 益肾疏肝法 临床研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R242[医药卫生—临床医学]