生物蛋白胶和谷氨酰胺对腹腔化疗后结肠吻合口愈合影响的研究  

The influence of fibrin glue and glutamine on the healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil

作　　者：石磊[1] 张松岩[1] 迟强[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医学院普通外三科,黑龙江哈尔滨150086

出　　处：《肠外与肠内营养》2007年第4期197-200,共4页Parenteral & Enteral Nutrition

摘　　要：目的:探讨大鼠在术后早期腹腔化疗的情况下,应用生物蛋白胶(FS)和谷氨酰胺(G ln)对结肠吻合口愈合的影响。方法:将32只大鼠随机分为四组,即对照组:于结肠吻合术后第1～3天,每天腹腔内注射0.9%NaC l 4mL;腹腔化疗组(5-FU组):于结肠吻合术后第1～3天,腹腔内注射5-氟尿嘧啶20 mL/kg(20 mg/mL);生物蛋白胶组(FS组):于结肠吻合术后,吻合口覆盖生物蛋白胶约1 mL,腹腔化疗同5-FU组;谷氨酰胺组(G ln组):手术和化疗同FS组,术后当天灌服G ln颗粒1 g/(kg.d)。观察吻合口评分、吻合口破裂压力和组织学情况。结果:G ln组和FS组吻合口破裂压力、吻合口愈合情况和生存率,明显高于5-FU组。结论:吻合口覆盖生物蛋白胶,应用G ln能明显促进腹腔化疗后结肠吻合口的愈合。Objective： To investigate the effects of fibrin glue （FS） and glutamine （Gin） on the healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil. Methods ： Thirty two female Wistar rats were randomized into four groups. After resection of a 1-cm seg- ment of the transverse colon, an end-end sutured anastomosis was performed. Then the rats were divided into control group, 5-FU group, FS group, and Gin group. All rats were killed on the 8th postoperative day and the anastomoses were examined microscopically. The bursting pressure measurements were recor- ded and anastomoses were graded histologically. Results： The adhesion formation score was significantly higer in the rats of the 5-FU group than in the other groups. Bursting pressures were also significantly lower in the 5-FU group than in the other groups. Conclusion ： The immediate postoperative intraperito- neal administration of 5-FU inhibited wound healing. However, FS and Gin can improve early healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil.

关 键 词：腹腔化疗 生物蛋白胶 谷氨酰胺 肠吻合 

分 类 号：R735.3[医药卫生—肿瘤]