大鼠下颌功能性前伸后髁突软骨雌激素含量变化的研究  

A study on the changes of the estrogen level in the condylar cartilages in young growing rats after functional mandibular protrusion

作　　者：白玉兴[1,2] 罗颂椒[1,2] 

机构地区：[1]华西医科大学口腔医学院 [2]首都医科大学附属北京口腔医院正畸科

出　　处：《中华口腔医学杂志》1997年第3期161-163,共3页Chinese Journal of Stomatology

基　　金：国家自然科学基金

摘　　要：为了深入探讨功能矫治的机理，了解雌激素与髁突软骨增生、分化及适应性生长改建的关系，应用放射免疫分析法对大鼠青春期生长过程中及下颌功能性前伸后，髁突软骨中雌二醇含量的变化进行了定量研究。结果表明，雌二醇与髁突软骨的增生、分化密切相关，下颌功能性前伸后，髁突软骨中雌二醇含量明显增加，对软骨的增生有促进作用。本研究的结果，进一步证实了髁突软骨生长改建的内分泌调控理论，为临床功能矫治提供了客观的实验依据。Fifty female SD rats of 4 week old were selected, divided equally and randomly into experimental and control groups. Simulated functional appliances were used to guide the mandibles of the rats forwards. The animals were sacrificed after 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks. The method of radioimmunoassay (RIA) was performed to quantitively detect the level of estrogen in the condylar cartilages. The results showed: 1. High levels of estrogen were detected in the condylar cartilages during their actively proliferative period. When they differentiated gradually, the levels of estrogen decreased. 2. The amount of estrogen was increased significantly after functional mandibular protrusion, especially during the peroid of the active proliferation of the condylar cartilages. It is suggested that estrogen has a close relationship with the hyperplasia and hypertrophy of the condylar chondrocytes and the increment of the levels of estrogen in the condylar cartilages will further promote the proliferation and functional adaptive remodelling of the condylar cartilages.

关 键 词：下颌骨前伸 髁突软骨 雌激素 

分 类 号：R782[医药卫生—口腔医学]