VEGF在子宫颈癌及上皮内瘤变中的表达  

A analysis on the expression of VEGF in the cervical carcinoma and cervical intraepithelial neoplasia

作　　者：姜星[1] 李敏[1] 雷瑛[1] 王庆一[1] 

机构地区：[1]广东省珠海市妇幼保健院妇科,519000

出　　处：《中国妇幼保健》2007年第32期4596-4598,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨VEGF在慢性宫颈炎、宫颈上皮内瘤变（CIN）及浸润性宫颈癌（ICC）中的表达，旨在提高宫颈上皮内瘤变及浸润性宫颈癌的诊断率。方法：采用免疫组化SP法检测40例慢性宫颈炎、30例CINⅠ～Ⅱ、25例CINⅢ以及30例ICC病例中VEGF的表达。结果：慢性宫颈炎组织、CINⅠ～Ⅱ组织中很少表达VEGF，在CINⅢ及ICC组织中呈高表达，二者之间有显著性差异（P〈0．05）。结论：VEGF在CINⅢ及ICC中呈高表达，是监测CIN及ICC的一个重要的指标，并有助于探讨CIN及ICC的发病机制。Objective： To explore the expression of vascular endothelial growth factor （VEGF） in the chronic cervicitis, cervical intraepithelial neoplasia （CIN） and invasive carcinoma of cervix （ICC） , in order to improve the the pre -operation diagnosis of CIN and ICC. Methods： Immunohistochemical technique was employed to study the expression of VEGF in 40 cases with the chronic cervicitis, 30 cases with CIN Ⅰ-Ⅱ, 25 cases with CIN Ⅲ and 30 cases with ICC. All cases were employed by HE stain. Results： The expression of VEGF in the chronic cervicitis and CIN Ⅰ-Ⅱ was little and remarkably lower than that of CINⅢ and ICC （P 〈0. 05） . Conclusion： The high expression of VEGF in CIN Ⅲ and ICC is a important indicator to detect the CINⅢ and ICC, it is useful to study the mechanism and to improve the diagnosis of CIN and ICC by detecting the expression of HPV.

关 键 词：VEGF 宫颈上皮内瘤变 浸润性宫颈癌 慢性宫颈炎 

分 类 号：R737.33[医药卫生—肿瘤]