人类β-肾上腺素受体基因的遗传多态性及其与肥胖的关系(英文)  

Genetic polymorphisms of human β-adrenergic receptor genes and their association with obesity

作　　者：刘昭前[1] 莫玮[1] 黄琼[1] 周宏灏[1] 

机构地区：[1]中南大学临床药理研究所,长沙410078

出　　处：《中南大学学报（医学版）》2007年第3期359-367,共9页Journal of Central South University ：Medical Science

基　　金：This work was supported by National Nature Science Foundation of China (30572230 and 30070880) ;Outstanding Teachers of Ministry of Education of the People’s Republic of China (2002-350)

摘　　要：在世界范围内,肥胖和超重的发生率正在稳步增长。过去有关候选基因的大量研究已经表明,大多数基因与人类脂肪组织中肥胖的发生相关。与人体体质量相关的40%以上的基因变异可以产生遗传差异。β-肾上腺素受体在人体能量平衡调节中扮演重要作用,交感神经系统的高度激活被认为与肥胖的发生密切相关。β-肾上腺素受体的单核苷酸多态性如β1-肾上腺素受体Gly389Arg,β2-肾上腺素受体Gln27Glu和β3-肾上腺素受体Trp64Arg已经被证明能够改变受体的功能,并与肥胖的发生有关。本文就β-肾上腺素受体的遗传多态性以及它们在肥胖发生中的作用作一综述。The prevalent rates of overweight and obesity are steadily increasing all over the world. Previous studies of some candidate genes have indicated that most of the genes are associated with obesity in human adipose tissue. As much as 40% of the variations in body mass could be attributed to genetic difference. The β-adrenergic receptor （β-AR） plays a major role in the regulation of energy balance in humans. A high sympathetic nervous system activity has been shown to be associated with obesity and is believed to have pathogenetic relevance. Several common single nucleotide polymorphisms （SNPs） including Gly389Arg in β-AR, Gln27Glu in β2-AR, and Trp64Arg in β3-AR in humans could alter receptor function and these variations ofβ-ARs were shown to have certain association with obesity. Here we summarize the genetic polymorphisms of human β-ARs and their potential impacts to obesity.

关 键 词：Β肾上腺素受体 单核苷酸多态性 单倍体 脂肪分解 肥胖 

分 类 号：R589.2[医药卫生—内分泌]