等容稀释加多巴酚丁胺和胞二磷胆碱治疗脑血管痉挛的研究  

Study on Cerebral Vasospasm with Isovolemic Hemodilution and Dobutamine and Cytidine Disphisphate Choline (CDPC)

作　　者：林志国[1] 戴钦舜[1] 刘相轸[1] 刘恩重[1] 叶远柱[1] 杨遇春[1] 邹玉梅[1] 张英茹[1] 刘风华[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经外科

出　　处：《中国冶金工业医学杂志》1997年第2期79-80,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的：寻找一种有效的治疗脑血管痉挛的新方法。方法：蛛网膜下腔出血（ＳＡＨ）后所致的症状性脑血管痉挛（ＣＶＳ）病人１６例，采用等容稀释加多巴酚丁胺和胞二磷胆碱进行治疗。结果：治疗后脑电和ＣＴ检查正常。基底动脉ＴＣＤ血流速度和心输出量分别由治疗前的５１±１３．６ｃｍ／ｓ和４．６０±１．６Ｌ／ｍｉｎ增加到治疗后的７０±１２．６ｃｍ／ｓ和１１．５±２．８６Ｌ／ｍｉｎ（Ｐ＜０．０５）。除两例肢体肌力由原来的Ⅲ级恢复到Ⅳ级外，其余均恢复正常。总有效率高达９４％。结论：该法治疗ＣＶＳ有效。Objective:To find an effective method of treating cerebral vasospasm.Methods:Sixteen cases with symptomatic vasospasm after SAH were treated with isovolemic hemodilution and dobutamine and CDPC.Results:EEG and CT examination was normal after treating.Blood veloctities of basilar artery TCD (70±12 6 cm/s) in patients treated with this method and cardiac output (11 5±2 86 L/min) were higher than those (51±13 6 cm/s and 4 60±1 61 L/min respectively) in patients without treating (P<0 05).Myodynamia also returned to normal besides 2 patients.The cure rate was 94%.Conclusions:Patients who suffered from cerebral vasospasm could be treated with this method.

关 键 词：蛛网膜下腔出血 多巴酚丁胺 胞二磷胆碱 

分 类 号：R743.350.5[医药卫生—神经病学与精神病学]