上皮钙粘附蛋白在胃癌及其淋巴结组织中表达的生物学意义  

Biological Implication of the Expression of E-cadherin in Gastric Carcinoma and Its Lymph Node Metastasis

作　　者：陈忠 叶智勇 丁斌 

机构地区：[1]福建省永安市立医院病理科,366000

出　　处：《医学理论与实践》2007年第11期1246-1249,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨上皮钙粘附蛋白(E-cadherin,E-cad)与胃癌临床病理学特征的关系。方法:应用免疫组化SP法对80例胃癌及其转移淋巴结组织进行E-cad蛋白检测。结果:80例胃癌组织标本中E-cad表达率为55.00%。E-cad在胃癌组织中的表达与胃癌Lauren分型、分化程度、临床分期、浸润深度、淋巴结转移和远处转移显著相关(P<0.05),而与患者性别、年龄、肿瘤大小等参数无相关性。E-cad在有淋巴结转移的胃癌中原发灶和转移淋巴结中的表达率分别为35.48%和32.26%。E-cad的表达与有淋巴结转移的胃癌中的原发灶和转移淋巴结呈显著相关(列联系数R=0.4978,P<0.05)。结论:E-cad的表达与胃癌分化、侵袭转移密切相关。　Objective：To investigate the associations of the expression level of E-cadherin with the clinicopathological features of gastric carcinomas.Methods：The expression level of E-cadherin in 80 cases of gastric carcinomas and their metastaic lymph node tissues were examined by immunohistochemical assays.Results：The expression rate of E-cadherin in 80 cases of gastric carcinomas was 55.00%.The expression level of E-cadherin was positively correlated with the Lauren classification,the degree of histological differentiation,the clinical stage,the depth of invasion,lymph node metastasis and distant metastasis（P〈0.05）,but was not correlated to patient＇s sex, age and tumor size.The expression rates of E-cadherin in metastatic gastric carcinoma of primary lesions and lymph nodes metastasis were 35.48% and 32.26%,respectively.Furthermore,E-cadherin expression in metastatic gastric carcinoma was significantly correlated with primary lesions and lymph nodes metastasis（Pearson correlation coefficient R=0.4978,P〈0.05）.Conclusion：The expression level of E-cadherin in gastric carcinoma was closely correlated with the degree of tumor differentiation,infiltration and transferring.

关 键 词：胃肿瘤 淋巴结转移 E-钙粘附蛋白 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]