己酮可可碱促进学习记忆作用的实验研究  

Pentoxifylline promotes learning and memory function of aging rats and mice with induced memory impairment

作　　者：胡锐[1] 袁秉祥[1] 苏联珍[2] 魏霞蓁[2] 赵丽梅[1] 康军[1] 陈东[2] 

机构地区：[1]西安交通大学药理系 [2]天奎生物医药公司,陕西西安710061

出　　处：《南方医科大学学报》2007年第11期1734-1737,共4页Journal of Southern Medical University

摘　　要：目的探讨己酮可可碱对三种学习记忆障碍模型的作用。方法观察己酮可可碱对自然衰老痴呆模型大鼠(Morris水迷宫法)、东莨菪碱所致记忆获得障碍模型小鼠(跳台法)和乙醇所致记忆再现障碍模型小鼠(跳台法)的学习记忆的影响。结果己酮可可碱大中小剂量组均能够不同程度缩短自然衰老痴呆模型大鼠定位航行实验的潜伏期(P<0.01或P<0.05),提高空间搜索实验的空间象限记忆频度(P<0.05);缩短东莨菪碱所致记忆获得障碍模型小鼠的触电潜伏期(P<0.01或P<0.01),减少错误次数(P<0.05);对乙醇所致记忆再现障碍模型小鼠的记忆障碍也有一定的改善作用,但无统计学意义。结论己酮可可碱具有改善学习记忆能力的作用。Objective To investigate the effects of pentoxifylline on rats and mice with learning and memory dysfunctions. Methods Morris water maze test was used to observe the effects of pentoxifylline on learning and memory of naturally aging rats, and jumping stand test was performed to examine its effects in promoting the learning and memory functions in mice with scopolamine- and ethanol-induced memory dysfunctions. Results In aging rats, pentoxifylline at high, moderate and low doses all significantly reduced the latency of platform finding in the place navigation test （P〈0.01 or P〈0.05 ）, and increased the quadrant searching frequency in the spatial probe test （P〈0.05）. Pentoxifylline at the 3 doses significantly increased the latency of electrification （P〈0.01 or P〈0.05） and decreased the times of error （P〈0.05） of the mice as compared with scopolaminetreated group. Pentoxifylline also improved ethanol-induced memory dysfunction in the mice, but the changes in the performance of the mice were not statistically significant. Conclusion Pentoxifylline can improve the learning and memory abilities of rats and mice.

关 键 词：己酮可可碱 阿尔茨海默病 学习 记忆 morris水迷宫法 跳台法 

分 类 号：R749.16[医药卫生—神经病学与精神病学]