腋窝淋巴结阴性乳腺癌206例预后因素分析  

Prognosis Analysis of Node-Negative Breast Cancer Patients Report of 206 Cases

作　　者：邢镨元[1] 罗扬[1] 何静[1] 冯奉仪[1] 

机构地区：[1]中国医学科学院肿瘤医院,100021

出　　处：《实用癌症杂志》2007年第6期641-644,647,共5页The Practical Journal of Cancer

摘　　要：目的探讨腋窝淋巴结阴性乳腺癌的临床特点、治疗方法及预后的影响因素。方法收集206例腋窝淋巴结阴性乳腺癌患者的临床病理资料,应用Kaplan-Meier法计算生存率,应用log-rank检验各组生存率,采用COX比例风险模型进行多因素分析。结果全组患者5年无复发生存率为83.5%,总生存率为95.6%。单因素分析显示,年龄(P=0.0137)、肿块大小(P=0.0002)、术后放疗(P=0.0176)、化疗(P=0.0104)、内分泌治疗(P=0.0091)是影响淋巴结阴性乳腺癌患者5年无病生存的因素;年龄(P=0.0113)、肿块大小(P=0.0375)、ER(P=0.0046)、PR(P=0.0275)是影响淋巴结阴性乳腺癌患者5年总生存的因素。多因素分析显示,肿块大小(P=0.002)是影响淋巴结阴性乳腺癌患者5年无病生存的独立预后因素。结论肿块大小是影响淋巴结阴性乳腺癌患者5年无病生存的独立预后因素。Objective This study was to investigate the clinical eharaetersties,effeetive treatment and prognosis in patients with early node-negative breast cancer. Methods The data of 206 node-negative breast cancer patients were retrospectively reviewed. The survival rate was calculated by Kaplan-Meier method and compared by log-rank test. COX multivariate prognosis analysis was performed. Results The 5-year disease-free survival rate of the 206 patients was 83.5 %, and the 5-year overall survival rate was 95.6%. Univariate analysis showed that age（ P = 0, 0137 ）, tumor size （P = 0. 0002 ）, adjuvant radiotherapy （P = 0.0176）, adjuvant chemotherapy （ P = 0.0104 ）, adjuvant hormonal therapy were prognostic factors of early node-negative breast cancer in 5-year disease-free survival rate. Age（ P = 0.0113 ） ,tumor size（ P = 0.0375 ） ,expression of ER（ P = 0. 0046 ） or PR（ P = 0.0275 ） were prognostic factors of node-negative breast cancer in 5-year overall survival rate. Multivariate analysis showed that tumor size（ P = 0. 002 ） was independent prognostic factors in 5-year disease-free survival rate. Conclusion The tumor size is independent prognostic factors of node-negative breast cancer in 5-year disease-free survival rate.

关 键 词：乳腺癌 腋窝淋巴结 单因素分析 多因素分析 

分 类 号：R739.9[医药卫生—肿瘤]