血管形成因子和炎性肠病相关性的研究进展  

Updated correlation between angiopoietic factors and inflammatory bowel disease

作　　者：涂频[1] 张新华[1] 周晓军[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)病理科,江苏南京210002

出　　处：《医学研究生学报》2007年第11期1223-1226,共4页Journal of Medical Postgraduates

基　　金：南京军区南京总医院科研基金资助项目(批准号:2005111)

摘　　要：炎性肠病是一种病因不明的肠道非特异性炎性疾病,主要包括克罗恩病和溃疡性结肠炎。近年来研究发现,血管生成在炎性肠病中具有十分重要的意义。许多因子可以促进血管的生成,诸如纤维生长因子-2、白细胞介素-8、血小板源性生长因子、转化生长因子β,特别是血管内皮生长因子。作者就炎性肠病血管生成的相关因子作一综述。Inflammatory bowel disease （IBD）, the precise etiology of which remains unknown, is comprised of two forms of chronic intestinal inflammation, ulcerative colitis and Crohn＇s disease. Recent researches suggest that angiopoiesis plays an important role in the development of IBD. Many cytokines can enhance angiopoiesis, such as fibroblast growth factor-2, interleukin-8, transforming factor-β and particularly vascular endothelial platelet-derived growth factor, factor. This review summarizes the angiopoietic factors correlated with IBD. K

关 键 词：血管形成因子 炎性肠病 血管内皮生长因子 

分 类 号：R574.5[医药卫生—消化系统]