首发脑卒中后抑郁的事件相关电位研究探讨  

Research of events related potentials to initial post-stroke depression

作　　者：周志强[1] 郑永玲[1] 金涛[1] 

机构地区：[1]重庆市第三人民医院神经内科,40014

出　　处：《重庆医学》2007年第13期1242-1243,共2页Chongqing medicine

摘　　要：目的通过对脑卒中后抑郁患者的事件相关电位(ERPs)研究,探讨脑卒中后抑郁对脑卒中患者的认知及肢体功能的影响和相关性。方法用听觉oddball刺激序列ERP检测64例脑卒中患者,其中脑梗死38例,脑出血16例。均经汉密尔顿抑郁量表(HAMD)、Zung氏抑郁自评量表(SDS)、简易精神状态检查法(MMSE)及神经功能缺损评分测查。结果脑卒中后抑郁患者组与无抑郁患者组相比P300潜伏期显著延长(P<0.01),且波幅显著降低(P<0.01);两者MMSE及神经功能缺损评分差异具有统计学意义(P<0.05)。结论脑卒中后患者抑郁的发生与患者的认知功能及肢体功能呈现显著的相关性,可通过ERPs的检查提高对脑卒中后抑郁,认知障碍的识别。Objective To investigate the effect of post-stroke depression on cognitive and limb function and relationship in stroke patients. Methods Sixty-four stroke patients, 38 of infarction and 16 of cerebral hemorrhage, were assessed by auditory oddball stimulus to evoke events related potentials. All cases were tested by HAMD, SDS, MMSE and nerve functional deficit. Results Post-stroke depression patients were compared with the patients without depression, the significant difference was found in latent period and amplitude of P300 （P〈0.01）. Conclusion The significant relationship exists between occurrence of post-stroke depression and cognitive and limb function in stroke patients. ERPs test might improve the recognition to depression and functional deficit of post-stroke.

关 键 词：脑卒中 抑郁症 事件相关电位 

分 类 号：R749.1[医药卫生—神经病学与精神病学]