急性髓系白血病细胞遗传学的分型诊断意义  

SIGNIFICANCE OF CYTOGENETIC ANALYSIS IN DIAGNOSIS AND SUBCLASSIFICATION OF ACUTE MYELOID LEUKEMIA

作　　者：肖志坚[1] 卞寿庚[1] 李建波[1] 薛艳萍[1] 秘营昌[1] 钱林生[1] 赵耀中[1] 郝玉书[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所

出　　处：《中华医学遗传学杂志》1997年第3期155-156,共2页Chinese Journal of Medical Genetics

摘　　要：为探讨细胞遗传学在急性髓系白血病（ＡＭＬ）分型诊断中的意义，回顾性分析了１６７例原发性初诊ＡＭＬ患者的核型与ＡＭＬ亚型之间的关系。结果表明：６７．７％的患者有克隆性染色体异常，ｔ（８；２１）、ｔ（１５；１７）、ｉｎｖ（１６）／ｄｅｌ（１６）分别与Ｍ２ｂ、Ｍ３、Ｍ４Ｅｏ特异性相关，１１号染色体异常常见于Ｍ４、Ｍ５。细胞遗传学可作为ＡＭＬ亚型的分型诊断手段之一。To demonstrate the significance of cytogenetic analysis in diagnosing and subclassifying acute myeloid leukemia(AML),the karyotypes were analysed in 167 patients with de novo AML.67.6% of the cases were found to exhibit clonal chromosome abnormalities.t(8;21), t(15;17) and inv (16)/del(16) were specifically associated with M2b,M3 and M4Eo,respectively.Chromosome 11 abnormalities were often identified in M4 or M5.Cytogenetic studies could be used as a convenient tool for refined diagnosis and subclassification of AML.

关 键 词：白血病 急性 细胞遗传学 诊断 

分 类 号：R733.710.4[医药卫生—肿瘤]