肿瘤血管生成与抗血管生成基因治疗  

Tumor Angiogenesis and Anti-angiogenesis Gene Therapy

作　　者：张宁宁[1] 薛妍[1] 刘文超[1] 

机构地区：[1]第四军医大学西京医院肿瘤科,西安市710032

出　　处：《中国肿瘤临床》2007年第21期1253-1256,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:30572100)

摘　　要：肿瘤血管生成是肿瘤生长浸润转移的关键步骤,其形成主要是促血管生成因子和抑制因子作用失衡的结果。以肿瘤血管生成为靶点的抗血管生成治疗作为肿瘤治疗新视野,已发展为重要的抗肿瘤策略。基因治疗则使抗血管生成治疗更具有靶向性,使这一治疗策略产生新的飞跃。本文就该领域研究情况作一综述。Tumor angiogenesis is critical for tumor growth, invasion and metastasis. It occurs as a result of an imbalance between angiogenic cytokines and angiogenesis inhibitors. Targeting tumor angiogenesis is an important strategy in tumor treatment. Gene therapies deliver targeted anti-angiogenesis therapy. In this article, we review the current research on tumor angiogenesis and anti-angiogenesis gene therapy.

关 键 词：肿瘤 血管生成 抗血管生成 基因治疗 

分 类 号：R730.5[医药卫生—肿瘤]