肥胖青少年胰岛素抵抗和β细胞分泌功能的变化  

Changes of insulin resistance and β cell secretion in obese adolescents

作　　者：周黎黎[1] 孙勇[2] 何丽[1] 古来[1] 赵迎春[1] 阳新 刘光英[1] 崔童[1] 王瑜克[1] 韩致毅[1] 象仁欠[1] 欧阳伟钢[1] 

机构地区：[1]新疆克拉玛依市中心医院,新疆克拉玛依834000 [2]新疆医科大学,新疆乌鲁木齐830054

出　　处：《现代中西医结合杂志》2007年第34期5079-5081,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨肥胖青少年胰岛素抵抗和B细胞分泌功能的变化。方法对9969名11～19岁的中学生行肥胖筛查，纳入肥胖267例，超重185例，正常136例，分别行葡萄糖耐量试验，同时测量腰围、臀围，计算腰臀比、腰高比；据空腹和服糖30min、120min血糖、胰岛素值计算稳态模型胰岛素抵抗指数（HOMA-IR）和胰岛素分泌功能（HOMA-β、△Ins30/△Glu30）。结果3组腰围、臀围、腰臀比、腰高比和血胰岛素值均有显著性差异（P〈0．0001），餐后30min血糖在肥胖和正常组间有统计学差异（P〈0．0248）；3组间HOMA-IR、HOMA-β、△Ins30/△Glu30比较均有显著性差异。结论肥胖和超重者存在高胰岛素血症，可能存在胰岛素抵抗，肥胖青少年p细胞早相分泌功能可能受损。Objective It is to explore insulin resistance and β cell secretion in obese adolescents. Methods A standard glucose-tolerance test was administered to 267 obese ones, 185 overweight ones, and 136 normal ones chosen from 9969 middle school students of 11 - 19 years. Baseline measurements included the weight, height, waistline, Hip-circumference and BMI, WHR〈 WHTR. Serum glucose and insulin levels were determined at 0, 30, 120 min after OGTT, insulin resistance and secretion of β cell were estimated by homeostasis model assessment of insulin resistance （HOMA- IR） and secretion of β cell （HOMA-β, △Ins30/△Glu30）. Results There were significant differences among the three groups in waistline, Hip-circumference, WHR, WHTR and serum insulin levels （P 〈 0. 000 1）. Compared with that in obese group, the difference in serum glucose at 30 min after OGTT in normal group was significant （P 〈 0.05）, There were significant differences in HOMA- IR, HOMA - 13, △Ins30/△Glu30 among the three groups （P 〈 0, 01）, Conclusion The obese and overweight groups all have hyperinsulinemia, so there may be insulin resistance and impairment of early secretion of β - cell in obese adolescents.

关 键 词：肥胖 青少年 胰岛素抵抗 Β细胞分泌 

分 类 号：R587[医药卫生—内分泌]